410 



STROPHANTHUS SARMENTOSUS : ITS PHARMACOLOGICAL ACTION. 



Plate III. 

 Experiment. 



LI. Tracings of detached gastrocnemius muscles of frog. Read from left to right. 1, both muscles in 

 Ringer's solution only. 2, muscle B in a solution of S. sarmentosus extract in Ringer's solution 

 (1 in 10,000) shows little change. 3 and 4, muscle B has shortened, but elongates on relaxation. 



5, movements of the lever of B caused by coarse fibrillary twitches following repeated stimulation. 



6, muscle B does not respond with secondary at 120 mm. 7, response of B at 100 mm. S, feeble 

 contraction of B at 100 mm. 9, contractions of A and B at 80 mm. 



Plate IV. 



LX. Frog-heart tracings. 1, before, and 2 to 12, after application of extract of S. sarmentosus. 5, shows 

 abrupt contraction of auricles and their relaxation before ventricular systole. 6, shows diastolic 

 pauses. From 9 onwards, show paralysis of the ventricle before the auricles. 



Plate V. 

 LXI. Frog-heart tracings. 4 and 5, show increased amplitude of movement in the direction of systole. 



Plate VI. 



LXII. Frog-heart tracings. 1, before, and 2 to 11, after extract of S. sarmentosus. From 5 onwards, show 

 increased systolic movement of the ventricle, and increase in the length of the diastolic pause 

 In II, the paralysis of the auricles and ventricle in diastole is shown. 



Plate VII. 



LXIII. Frog-heart tracings. Fig. 4, shows marked slowing of the heart. Fig. 5, shows the arrest of the 

 ventricle in systole. 



Plate VIII. 



LXIV. Frog-heart tracings — isolated ventricle. 1 and 2, show rapid increase in the rate and extent of the 

 systolic contraction after extract of S. sarmentosus. 3, shows slowing and tendency to stop in 

 systole. 4, shows arrest of ventricle in diastole. 5, shows spontaneous movements of the 

 ventricle after a long pause in diastole. 



Plate IX. 



Curves of Experiments LXV. to LXVIIL, representing the effects produced on the blood-vessels of 

 frogs by perfusion with solutions of extract of S. sarmentosus followed by digitalin. 



Plate X. 



LXIX. Blood-pressure tracings from carotid artery of a rabbit. 1 and 2, before extract of S. sarmentosus. 

 3 to 13, after injection of the extract into a jugular vein (0 - 0009 gram per kilogram). These 

 tracings show a slight initial rise in blood-pressure, with increase of the pulse and respiratory 

 movements. 



Plate XL 



LXX. Blood-pressure tracings from carotid artery of a rabbit. 1, before extract of S. sarmentosus. 2 to 

 4, after injection of the extract into a jugular vein (0 , 0002 gram per kilogram), showing a slight 

 increase in the blood-pressure and in the pulse movements. 5 and 6, after a second injection of 

 0-0002 gram per kilogram into the same vein. 7 to 8, after a third injection of 0'0002 gram per 

 kilogram into the same vein, and showing a considerable increase in the pulse movements. 9 to 

 12, after a fourth injection of - 0002 gram per kilogram into the same vein, and showing 

 great increase in the pulse movements, and rapid variations of the blood-pressure and its final 

 fall to zero. 



PRESENTED 





