ON RESULTS OF REMOVAL AND TRANSPLANTATION OF OVARIES. 593 



Knauer (1896) removed an ovary from a rabbit and transplanted it upon the 

 uterine horn of the same side in the same individual. After several months he killed 

 the rabbit, when he found the grafted ovary, which contained Graafian follicles, some 

 degenerate but some apparently healthy. 



Grigorieff (1897) performed a series of experiments in which he transplanted 

 ovaries of adult rabbits to the broad ligament or the peritoneum of the vesico-uterine 

 pouch. Subsequently he found that the grafts had become successfully attached and 

 contained follicles in a state of complete preservation. In four cases pregnancy is 

 stated to have occurred, the ova being supposed to have been derived from the grafted 

 ovaries. 



Grigorieff also mentions two cases in which ovaries were transplanted from one 

 individual to another (heteroplastic grafting). Both of these are said to have been 

 successful, but no description is given of the transplanted ovaries. 



Arendt (1898), who attempted to transplant the ovaries of eleven rabbits to the 

 broad ligament, was unsuccessful in all cases. This author criticises the results 

 obtained by Knauer and Grigorieff, and concludes that in the cases of pregnancy 

 described by the latter the ova were produced in fragments of untransplanted ovarian 

 tissue which had been left in the normal position. Arendt expresses doubts as to the 

 possibility of successfully transplanting ovaries. 



Kibbert (1898), working on the guinea-pig, obtained results in homoplastic trans- 

 plantation which, in a general way, are confirmatory of those of Knauer and Grigorieff. 

 During the first month after transplantation the peripheral part of the grafted ovaries 

 remained unaltered but the central part became transformed into connective tissue. At 

 later periods, however, the central portion of the ovaries was again found to contain 

 follicles. Kibbert attributes this fact to the conditions of better nutrition which the 

 ovaries had probably attained after a month of transplantation. 



Rubinstein (1898) was also successful in transplanting rabbits' ovaries to abnormal 

 positions in the same individuals. 



Knauer, in a later paper (1899), has described certain further experiments in 

 transplanting ovaries. These were to a great extent successful. Knauer, however, 

 states that a portion of the grafted ovary invariably died, but the remaining part in 

 a large percentage of cases contained healthy follicles. Thirteen further cases are 

 mentioned in which an attempt was made to transplant ovaries from one individual 

 into another (heteroplastic transplantation), but each of these is reported as having 

 been unsuccessful. 



M'Cone (1899), in a preliminary report, briefly describes two cases of heteroplastic 

 grafting. In one of these the ovaries of a rabbit were implanted in another rabbit 

 (previously castrated), and the latter is stated to have subsequently given birth to five 

 young. In a second experiment the ovaries of a bitch are described as having been 

 successfully grafted upon a rabbit. Other experiments are mentioned in which 

 homoplastic transplantation (i.e. transplantation in the same individual) of rabbits' 



