382 PROFESSOR C. R. MARSHALL ON THE 



Brunton and Cash * with tetra-ethyl-ammonium iodide, and those of Jacobj and 

 Hagenberg t with tetra-ethyl-ammonium tri-iodide. Brunton and Cash, after 

 injecting hypodermically one gramme of tetra-ethyl-ammonium iodide into a rabbit, 

 observed trembling and shivering in eleven minutes, paresis of the fore part of the 

 body in twenty minutes, cessation of the respiration with persistence of the corneal 

 reflex in twenty-three minutes, and death in thirty-six minutes. After injecting 

 0*5 g. into a rabbit, the animal lay with its head on the table twenty-one minutes 

 after the administration, shaking from side to side. Five minutes later there were 

 convulsive springing, lurching, and shuffling, with dyspnoea. Death occurred thirty 

 minutes after the injection. Jacobj and Hagenberg state that hypodermic injections 

 of O'l g. to 0*25 g. tetra-ethyl-ammonium tri-iodide per kg. body-weight suspended 

 in glycerin, into cats, produced no symptoms. 



As the injection of 8 c.c. of a 2*5 per cent, solution of tetra-ethyl-ammonium 

 chloride into the peritoneal cavity of a rabbit weighing 1975 g. produced no 

 symptoms, intravenous medication was resorted to. The injections were made into 

 one of the veins of the ear, and occupied about one minute. The lethal dose was 

 found to be, for rabbits, about 0*05 g. per kg. body-weight. The intravenous 

 injection of 0*02 g. per kg. merely caused slight dyspnoea and slight tremors of the 

 fore part of the body a few minutes after the administration. Half this dose only 

 caused slight deepening of the respiration. After the administration of a small 

 lethal dose (0*06 g. per kg.) the animal remained normal and moved about for one 

 minute ; then the respiration became slower and the heart-beats somewhat faster, 

 and three minutes after the completion of the injection there appeared slight 

 spasmodic tremors with head-nodding. Half a minute later a second more powerful 

 tremor occurred, and twenty seconds later still more powerful tremors, which 

 continued ten seconds. Further similar spasms were few and slight and transient. 

 Five minutes after the termination of the injection the breathing was much slower 

 and somewhat gasping in character, and the heart-beats appeared somewhat more 

 forcible but were otherwise unchanged ; the animal sank on the table with the head 

 to one side, and from time to time moved slowly. Ten minutes after the injection 

 the respiration was still slower and air-hunger still more manifest ; the heart-beats 

 were somewhat slower and weaker. The corneal reflex was present. From six to 

 eight minutes later the animal made several spasmodic springs, after which the pupil 

 dilated and the cornea became insensitive. The respiration ceased twenty and a half 

 minutes after the cessation of the injection, and the heart-beats a few seconds later. 



The injection of 0*1 g. per kg. intravenously produced deep convulsive breathing 

 before the injection was completed. Erection of the tail and convulsive movements 

 of the hind limbs, which lasted for a few seconds, quickly followed, and the animal 

 then lay on its side paralysed. The corneal reflex was absent, but a few gasping 

 movements of the mouth occurred, the last about two minutes after the termination 



* Loc. cit., p. 210. t Loc. cit., p. 60. 



