490 



PROFESSOR C. R. MARSHALL ON THE 



chloride, and in the case of decerebrate animals powerful stimulation may occur ; but 

 no similar effects either on anaesthetised or decerebrate animals have been obtained 

 with tetra-ethyl-ammonium chloride. This preliminary stimulation in animals in 



Fig. 4. — Effect of tri-methyl-ethyl-ammonium chloride showing transient stimulation of respiration. Rabbit, 1700 g. 

 Ether. Letters as in fig. 1. First part of figure shows effect of injecting 3 mg., the second part of injecting 5 mg. 

 into right facial vein. 



which it occurred was also obtained after division of both vagi, and it would seem 

 to be due to an increased activity of the respiratory centre induced by the 

 substance. 



Apart from the stimulant action on the vagal terminations, which appears to be 

 peculiar to tetra-methyl-ammonium chloride, the action of the various alkyl- 

 ammonium compounds investigated is similar in character, although varying pro- 



