THE HISTOLOGY OF DISSEMINATED SCLEROSIS. 725 



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" (jber multiple Sklerose," Fortschritte der Medizin, 1910, xxviii, p. 640. 



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p. 2159. 

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1890, i, p.. 729. 

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 Westphal, " Uber Encephalomyelitis disseminata und arteriosclerotische Erkrankungen des Zentralnerven- 



systems in ihren Beziehungen zur multiplen Sklerose," Neurol. Centralbl., 1909, xxviii, p. 547. 

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1910, xxxix, p. 1. 

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xix, p. 373. 

 On the Relation of Spinal Diseases to the Distribution and Lesions of the Spinal Blood-vessels, 



London, 1895. 



"Review of the Etiology and Pathology of Multiple Sclerosis," Med. Chronicle, 1903, iv, p. 261. 



Diseases of the Spinal Cord, London, 1908. 



Wilson (Kinnier), "Progressive Lenticular Degeneration," Brain, 1912, xxxiv, p. 295. 

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Univ. Wien, 1909-1910, xviii, p. 1. 

 Zibgler, Lehrbuch der allg. Pathologie und path. Anatomie, Jena, 1906. 

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f. Nervenheilk., 1909, xxxvi, p. 440. 



DESCRIPTION OF PLATES. 



(Figs. 1-22 are from drawings ; figs. 23-456 are micro-photographs.) 



The illustrations are grouped together to follow as closely as possible the different sections of the 

 histological study. Plates XLVIII-LX give various levels of the brain and spinal cord in the different cases 

 and show the general topographical distribution of the areas (myelin sheath stain). In the remaining illus- 

 trations chief stress has been laid upon the evolution of the sclerotic areas and upon the sequence of the 

 changes in the individual tissue elements. 



Plates XLV-XLVII : 



Figs. 1-4. Evolution of a sclerotic area in the spinal cord through a stage of fat granule cell 

 formation — longitudinal direction of the nerve fibres. 

 „ 5-7. Ditto. Cerebral area : transverse direction of nerve fibres. 

 ,, 8-12. Ditto. Spinal cord : transverse direction of nerve fibres. 

 „ 13-15. Sequence in blood-vessel changes. 

 ,, 16-17. Related to axis cylinders. 



,, 18-20. ,, evolution of the fat granule cells ("Fettkbruchenzellen "). 



,, 21-22. ,, changes in the cerebral cortex. 



Plates XLVIII-LX. Topographical distribution of areas in Cases I-IX. 



„ LXI-LXV. Special features of spinal cord and cerebral areas. Weigert stain. 



„ LXVI-LXVII. Ditto. Marchi method. 

 TRANS. ROY. SOC. EDIN., VOL. L, PART III (NO. 18). 100 



