THE HISTOLOGY OF DISSEMINATED SCLEROSIS. 739 



Fig. 411, x 200. Cells in a demyelinated area showing chromatolysis and excentric nuclei. 



Figs. 412-413, x 75. Cells showing marked pigmentation both in myelinated and demyelinated 

 tissue. Weigert's myelin sheath stain. 



Fig. 414, x 275. Commencing reaction of the glia cells around a ganglion cell. Figs. 414-416, 

 polychrome methylene blue. 



Fig. 415, x 200. Atrophy and disappearance of ganglion cells with marked neuroglia cell reaction. 



Fig. 416, x 200. Similar to previous figure — occurring in the opposite anterior horn. 



Fig. 417, x 200. Ganglion cell, retaining its processes and chromophile structure, in the midst of 

 sclerotic tissue. Figs. 417-419, Heidenhain's ironhsematoxylin. 



Fig. 419, x 150. Disappearance, atrophy, and rounding of cells in the hypoglossal nucleus, witli 

 marked glia cell reaction. 



Fig. 419, x 200. One rounded atrophic ganglion cell present in the midst of a dense glia network. 



Fig. 420, x 200. Ganglion cells in one of the posterior root ganglia related to a completely 

 demyelinated area. Polychrome methylene blue. 



Plate LXXVI. 



Figs. 421-432. Changes related to the axis cylinders. 



Fig. 421, x 10. Intersection in the median raphe of the pons of persistent axis cylinders. Note the 

 darker staining of the still myelinated tissue on both sides (cf. figs. 16, 17, 44, and 289). 



Fig. 422, x 300. Persistent swollen axis cylinders in a medullary ray. 



Fig. 423, x 200, and fig. 424, x 50. Persistent axis cylinders continued as shadowy lines into the 

 dense sclerotic tissue ; longitudinal sections of cord. Figs. 421-424, Bielschowsky- Williamson silver method. 



Figs. 425 and 426, x 300. Granular disintegration of the axis cylinders in a sclerosing area. Hsema- 

 toxylin and eosin. 



Figs. 427 and 428, x 200. Persistent swollen axis cylinders in cross section ; posterior columns of the 

 cord. Bielschowsky-Williamson silver method. 



Fig. 429. Complete retention of axis cylinders ; longitudinal section of the cord. Figs. 429-432, Cajal's 

 silver method. x 200. 



Fig. 430. Small area in cerebral white matter ; axis cylinder network. 



Figs. 431 and 432. Axis cylinder contact in optic chiasma and nerves which were completely gelatinous. 



Plate LXXVII. 



Figs. 433-444. Sequence of changes in the blood-vessels (pp. 614-616) ; cf. figs. 13-15. 



Fig. 433. Area in longitudinal section "of the spinal cord showing capillary and transition vessels with 

 rows of fat granule cells (c) in their adventitia. Van Gieson's stain, x 60. 



Figs. 434-437. Blood-vessels in the cerebral white matter. Heidenhain's iron-haematoxylin. x 200. 

 Fig. 434, vessel cut transversely (b) with fat granule cells (c) in its adventitial lymph spaces, and glia cell 

 reaction (a) in the surrounding tissue; fig. 435, x 200, similar vessel cut longitudinally; fig. 436, x 400, 

 H.P. of previous figure to show the relation of the glia " Fuss " to the outer layers of the adventitia ; fig. 

 437, x 75, vessel surrounded by concentric layers of glia fibrils. 



Fig. 438. Vessel in the posterior median fissure ; adventitial lymph spaces filled by fat granule cells 

 which have been drained from the surrounding sclerotic tissue. Van Gieson's stain, x 250. 



Fig. 439 (cf. fig. 14). Transition vessel to show the cell content of the adventitia during the stage of 

 advancing sclerosis. Van Gieson's stain, x 370. 



Fig. 440. Condensed " hyaline " vessel (a) with the outer layers (b) of its adventitia still separated. 

 Note lessening cell content of the vessel wall. Iron-hsematoxylin. x 360. 



Fig. 441. Similar vessels with the peri-vascular spaces (artefacts) filled with a coagulum (a). Van 

 Gieson's stain, x 70. 



Fig. 442, x 60. Lateral columns of the spinal cord ; radiating longitudinal thickened vessels (a). 

 Figs. 442-444, Kulschitsky-Pal with picro-fuchsin. 



