900 



SIR THOMAS R. FRASER ON THE 



Table III. — Poison of Arrow-heads from Captain Macdonald, I.M.S. 

 Rabbits. — Injection under the skin of the abdomen. 



Date. 



Weight 



of 

 Animal. 



Dose 



per 



Kilo. 



Actual 

 Dose. 



1911. 









Nov. 1 



1230 



0-016 



002 



1912. 









April 13 



1965 



0-05 



0-0982 



„ 17 



1790 



0-075 



0-134 



., 11 



1700 



o-i 



0-17 



Result. 



Recovery. 



Recovery. 



Death in about 

 2 hours 10 

 mins. 



Death in 1 hour 

 5 mins. 



Notes. 



No symptom observed. 



Cardio - respiratory dislocation. Salivation. 



Motor weakness. Slight asphyxial spasms. 

 Do. do. 



Do. do. Increase of lachrymal secretion. 

 After death, spontaneous twitches of left 

 auricle, but no cardiac contraction followed 

 mechanical irritation of the dilated ventricles. 



Table IV. — Poisoned Arrow-heads from Captain Macdonald, I.M.S. 

 Frogs. — Injection into the lower dorsal lymph space. 



Date. 



Weight 



of 

 Animal. 



Dose 



per 



Kilo. 



Actual 

 Dose. 



Result. 



Notes. 



1912. 













May 9 



38 



0-0525 



0002 



Recovery. 



Distinct cardio-respiratory dislocation. Cheyne- 

 Stokes respiration. 



April 8 



32 



0-12 



0-0038 



Death in 5 to 6 

 days. 



Distinct cardio-respiratory dislocation. Dia- 

 phoretic frothing. Dropsy. 



,. 4 



38 



0-15 



0-0057 



Death in 2 to 3 

 days. 



Much cardio-respiratory dislocation. Motor 

 paralysis. Dropsy. 



May 20 



38 



0-15 



0-0057 



Death in 5 to 6 

 days. 



Cardio - respiratory dislocation. Diaphoretic 

 frothing. 



April 6 



37 



0-18 



0-006 



Death in about 

 6 days. 



Much cardio-respiratory dislocation. Much dia- 

 phoretic frothing. Motor paralysis. Dropsy. 



June 15 



40 



0-2 



0082 



Death in 3 to 4 

 days. 



Much cardio-respiratory dislocation. Much dia- 

 phoretic frothing. Moderate oedema. 



April 15 



30 



0-3 



0-009 



Death in 2 to 3 

 days. 



Much cardio-respiratory dislocation. Much dia- 

 phoretic frothing. Motor and cardiac weak- 

 ness. Moderate dropsy. 



roots was separately weighed, and was suspended in 0-25 to 0'4 c.c. of distilled water or normal saline, unless 

 the dose was too minute for separate weighing, in which case a suspension, made on the day of administration, of 

 definite strength in a weak solution of gum arabic was subdivided so as to obtain the required dose ; and this plan 

 was also adopted with the ether extract of the Government of India arrow-poison and with croton oil, which, 

 accordingly, were administered in the form of very weak emulsions. 



Weights of animals and doses of substances are stated in grammes and parts of a gramme. 



