906 



SIB THOMAS R. FRASER ON THE 



Table X. — Poison of Abob (Mishmi) Arrows prom Colonel Bailey, R.E. 

 and Captain F. M. Bailey. 



Frogs. — Injection into the loiotr dorsal lymph space. 



Date. 



Weight 



of 

 Animal. 



Dose 



per 



Kilo. 



Actual 



Dose. 



Result. 



Notes. 



1914. 













June 26 



21 



0-025 



0-000525 



Recovery. 



Slight cardio-respiratory dislocation. 



„ 25 



20 



0-05 



0-001 



Recovery. 



Much cardio-respiratory dislocation, with also 

 slowing, in 30 minutes, of the heart's rate. 

 Much motor weakness. 



July 7 



24 



00625 



0-0015 



Death in about 

 3 days. 



Do., with Cheyne-Stokes respiration, do. Dia- 

 phoretic frothing. Much motor weakness. 

 Swelling, especially abdominal, and partly 

 from accumulation in bladder. 



June 29 



28 



0-075 



0-0021 



Death in less 

 than 24 hrs. 



Do. do. Much early motor weakness. 



,, 24 



22 



01 



0-002 



Death in less 

 than 24 hrs. 



Do. do. Diaphoretic frothing. 



„ 23 



22 



0-2 



0-004 



Death in from 

 2 to 3 hrs. 



Much cardio-respiratory dislocation with early 

 slowing of heart. Much motor weakness, 

 beginning in about 10 minutes. Reflexes 

 early much weakened. 



July 13 



47 

 {Rana es- 

 culenta) 



o-i 



0-0047 



Death in from 

 5 to 6 hrs. 



Do. do. Diaphoretic frothing. 



In mammals and birds, accordingly, the poison of these arrows is more powerful 

 than the poisons of Captain Macdonald's and Lieut. -Colonel Sir Wyville Thomson's 

 arrows, being in rats twenty times more lethal than the former and five times more 

 lethal than the latter. Further, the lethal power is much greater in guinea-pigs 

 and somewhat greater in pigeons than in rats. 



With this greater lethality in warm-blooded animals, it is, even more remarkably 

 than the latter arrow-poisons, less active in frogs, having in them only about one- 

 tenth the lethal power that is displayed in warm-blooded animals. For further 

 remarks on this subject, see p. 909. The greater activity in mammals and birds of 

 Colonel Bailey's arrow-poison may probably be explained by its having been more 

 recently prepared, rather than because a different species of aconite had been used in its 

 preparation, as it is well known that aconite deteriorates under exposure and dampness. 

 As the aconite root in this collection, also, was unaccompanied with such other 

 parts of the plant as would admit of its specific identification, it appeared unnecessary 

 to make many experiments with an unknown species ; but a sufficient number were 

 made to prove that it has the same characteristic action of aconite as the arrow- 

 poison itself. 



Experiments made on mammals and frogs with the powdered cotyledon of the 

 seed contained in the Entada scandens legume resulted in showing that it is not 



