914 



SIR THOMAS R. FRASER ON THE 



(I me rally, a few days after the administration the animals again began to eat well 

 and even to gain weight, so that they soon became actually heavier than before the 

 administration, although inflammatory thickening and even moderate suppuration 

 were still present at the situation of injection. 



This absence of general effects and of other evidence of the entrance into the 

 blood of any toxic substance that had been introduced under the skin was not, 

 however, manifested in frogs. The experiments on these animals are recorded in 

 Table XV. 



Table XV. — Poison of Abor Arrows from the Government of India. 

 Frogs. — Injection into the lower dorsal lymph space. 



Date. 



1912. 

 Mar. 31 

 .. 31 



„ 31 

 Oct. 5 



Weight 



of 

 Animal. 



35 



28 



27 

 22-5 



21-5 



Dose 



per 



Kilo. 



o-ooi 



0-002 



0-004 

 0-005 



0-01 



May 1 



20-5 



25 



02 



Actual 

 Dose. 



0-000035 

 0-000056 



0000108 

 0-000112 



0-000215 



0-025 



0-0004 



000062 



Result. 



Recovery. 

 Recovery. 



Recovery. 



Death in from 

 10 to 11 days. 



Death in from 

 4 days 5 hrs. 

 to 4 days 15 

 hrs. 



Death in more 

 than 2 and 

 less than 3 

 days. 



Deatli between 

 2nd and 3rd 

 days. 



Notes. 



No effect observed. 



No effect for 6 days, when blood was passed 

 per ano, and this was repeated, at irregular 

 intervals, during the following 30 days. No 

 effect on heart, respirations, or motility. 



No effect observed excepting a little blood 

 per ano on 22nd day. 



Moderate swelling of body and throat, with 

 discoloration at dorsum, where afterwards a 

 small shallow ulcer appeared. After death, 

 purplish-red discoloration under skin of 

 back, extending slightly to both thighs. 

 Roof and floor of mouth congested. Blood 

 in stomach and rectum. 



No definite symptom observed, only weakness 

 and discoloration of back. After death, 

 congestion and haemorrhages on floor and 

 roof of mouth, where cedematous swelling. 

 Considerable quantity of blood in stomach, 

 less in rectum, and very little in intestines. 

 Congestion of lungs and liver. 



No definite symptom observed. After death, 

 swelling of back and purplish discoloration 

 from anus to base of head ; under skin 

 of back blood-stained serum ; many large 

 haemorrhages there from urostyle to base 

 of eyes, and a few in axillae and below 

 skin of lower jaw. Abdominal viscera con- 

 gested. In stomach much blood, in small 

 intestines none, and in rectum a considerable 

 quantity. 



On 2nd day some haemorrhage, apparently 

 from mouth or nares. After death, sub- 

 cutaneous congestion and haemorrhages over 

 back. Much dark and sanguineous liquid in 

 stomach and intestines, giving the reactions 

 of blood. 



