910 



SIR THOMAS R. FRASER ON THE 



under that of a leg below the knee. The results of these experiments are recorded 

 in Tables XVI and XVII. 



Table XVI. — Poison of Abor Arrows from the Government of India. 

 Frogs. — Injection under the skin of a thigh. 



Date. 



1914. 

 Oct. 19 



„ 19 



Weight 



of 

 Animal. 



30 



29-5 



17-5 



Dose 



per 



Kilo. 



0-005 



0-025 



0-05 



0-1 



Actual 

 Dose. 



0-00015 



000045 



0-00148 



000175 



Result. 



1 was killed on 

 50th day. 



Death in 

 3 days. 



2 to 



Death in 

 4 days. 



3 to 



Death in about 

 2 days. 



Notes. 



Blood passed on 26th, 29th, 36th, 44th, and 46th 

 days, and moderate swelling with discoloration 

 of injected thigh. No other symptom. After 

 death, haemorrhages in injected thigh. Con- 

 siderable quantity of blood in large intestine, 

 but none in stomach or small intestines. 



Swelling and discoloration of thigh, leg, and 

 foot of injected limb. Some feebleness in 

 movements on 3rd day. After death, water in 

 frog dish gave blood reactions ; muscles of thigh 

 and foot of injected limb reddish purple, with 

 many hsemorrhagic spots ; haemorrhages also in 

 the muscles of opposite thigh and at the uro- 

 style. A little blood in stomach and small 

 intestines, and a considerable quantity in large 

 intestine. 



Very little effect observed during life except 

 motor weakness and discoloration of injected 

 leg. After death, skin and muscles of injected 

 thigh, leg, and foot dark and hsemorrhagic, and 

 slight hsemorrhages in thigh of opposite limb. 

 In stomach much blood, in duodenum a trace, 

 and in large intestine none (Plate C, fig. 2). 



No symptom observed but model ate motor weak- 

 ness on 2nd day. After death, large and small 

 hsemorrhages in thigh and leg of injected limb, 

 considerable haemorrhage in opposite thigh 

 and urostyle, and punctiform hsemorrhages on 

 and in pectoral muscles. Much blood in 

 stomach and small intestines and a little in 

 lanje intestine. 



In the greater number of these experiments, haemorrhages occurred in the 

 alimentary canal and also in the subcutaneous and muscular tissues of the limbs 

 into which the poison had not been injected. 



