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XVII.—Multiple Neuromata of the Central Nervous System: their Structure 
and Histogenesis.* By the late Alexander Bruce, M.D., LL.D., F.R.C.P.E. ; 
and James W. Dawson, M.D. (Carnegie Research Fellow). Communicated 
by A. Nintan Bruce, M.D., D.Sc., M.R.C.P.E. (From the Royal College of 
Physicians’ Laboratory, Edinburgh.) (With Hight Plates.) 
(MS. received April 23,1912. Read July 1, 1912. Issued separately January 9, 1913.) 
CONTENTS. 
7 PAGE PAGE 
1, The Genesis of Peripheral Nerves . so) 6 RD (c) Origin of the fibres. . 755 
(1) Embryogenesis . 702 (d) Distribution : 6 . 758 
Note on the genesis of fibres in the (2) Fibrosis associated with the 
central nervous system , 5 (ale nodules. 760 
(2) Histogenesis in regeneration : 714 (3) Fibrosis of the intra- medullary 
Note on the regeneration of fibres portions of the anterior and 
in the central nervous system . 726 posterior roots . F ; . 763 
(8) Histogenesis in tumour formation . 730 4) Sclerosis. ‘ . 164 
(a) Ganglio-neuroma : Pioe 2. Medulla oblongata and. pons, ; . 765 
(b) Neuroma . : : . 736 (1) Isolated nucleated patches . 5 RD 
(c) Neuro-fibroma . 737 (2) Changes in relation to the intra- 
Note on the genesis of fibres in medullary course of sensory 
tumours of the central nervous roots 771 
system . - 73h) (3) Patches composed of interlacing 
(a) Glioma and neuro- o-glioma . 739 nucleated fibres and fusiform 
(b ) Neuroma . 739 nucleated elements . : Se 
istological Study of Multiple Neuromata of (4) Nodule formation : 775 
the Central Nervous System : . 144 (5) Changes in relation to the super- 
1. Spinal cord . : , ; . 745 ficial origin of motor cranial 
(1) Nodule formation j . 748 merves . ; é ; = do 
(a) Disposition of the fibres . 749 (6) Fibrosis : 5 : 3 5 OS 
(6) Structure and mode of for- III. Interpretation . , ; : j . 780 
mation . : . . 750 Conclusion : : 0 - ; . 790 
Recent investigations have profoundly modified our conception of the value of the 
ological elements of the nervous system. Conflicting opinions are still held on 
y points of primary importance, perhaps the chief of which is the relation of the 
rve fibre to the nerve cell. The origin of the nerve fibre is a problem of vital interest 
; only to the embryologist, but also to the physiologist and the pathologist. It has 
long been the subject of controversy, and, in spite of numerous valuable researches, we 
still far from knowing the relation of the nerve fibre to the central neuroblast, a 
tion of essential importance in the understanding of all neuro-pathological questions. 
Researches on the embryogenesis and mode of regeneration of the peripheral nerves 
z _* [Note by Dr Jamus Rircute, Superintendent, Royal Callers of Physicians’ Laboratory.—During Dr ALEXANDER 
Br uce’s lifetime a full investigation had been made of the spinal cord of the case which is the subject of this paper. 
The characters of the neuromata and their connections with the aberrant nerve fibres present had been considered 
and were the subject of a preliminary communication before the Pathological Society of Great Britain and Tveland 
910 (see Journ. Path. and Bacteriol., Cambridge, vol. xv. (1911), p. 127). It was not until after Dr Brucn’s death, 
ever, that the medulla was examined and the younger nodules present discovered. Dr Dawson is thus Sespohaible 
that part of the paper which deals with the bearing of these later observations on the origin of the tumours and on 
significance of the underlying processes in relation to the question of the embryology of nerve fibrils generally. ] 
TRANS. ROY. SOC. EDIN., VOL. XLVIII. PART III. (NO. 27). 101 
