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MULTIPLE NEUROMATA OF THE CENTRAL NERVOUS SYSTEM. 741 
(1901), in two similar cases, and Hauser (1901), in three, mention the finding in the 
central glious tissue of isolated nerve fibres or definite nodules composed of tortuous 
medullated fibres with the structure of peripheral nerves. In all of the above the 
nodules were often sharply delimited, and nowhere did the fibres of the periphery 
seem to be prolonged into the surrounding tissue. BiscHoFSWERDER draws attention 
to the frequent presence of vessels in the centre or at the periphery of nodules, and 
suggests that this fact may throw some light upon their origin. 
NaGkoTtre (1899), in tabes and in a case of hemisection of the cord, has found 
nerve fibres, isolated and in bundles, in all parts of the pia, but especially near the 
point of emergence of the anterior roots. FICKLER (1900), in a case of compression of 
the cord, has found medullated fibres filling the anterior fissure from the adjoining pia. 
The significance of these findings of NagEorrE and Fickusr has already been referred to 
in the note on regeneration of fibres in the central nervous system. 
Pick (1900) has described nodules composed of unstriped muscle fibres around 
the spinal cord vessels. Prick had previously, in 1895, described similar formations 
around the vessels of the pia, and had explained them as circumscribed prolifera- 
tions of muscle fibres of otherwise normal vessels. HertiicH later drew attention to 
the possibility of Picx’s leio-myoma of the pia and cord being true neuroma, which 
on account of their fascicular structure and elongated nuclei gave the appearance of 
leio-myoma. 
Taomas, Toucue, and Jacos (1901) described a case of Pott’s disease following a 
fracture two years before death. The 8th cervical segment was compressed, and in 
the anterior fissure, immediately above the point of compression, were found very 
numerous nodules composed of fibres with the structure of peripheral nerves. Small 
‘“neuromata composed of a few bundles of fibres were found also in the pia round the 
whole circumference of the cord at this level, and in the lateral column of the right 
side there was present a small nodule which at one point reached the pia. In none of 
the nodules could the origin of the fibres be traced, but the writers ascribe their 
formation without doubt to regenerative processes and believe that the new fibres 
have their origin from the fibres of the tracts interrupted at the level of the compression. 
Dercum and SpiLER (1901) have described non-myelinated fibres in the pia covering 
the posterior columns in a case of adiposis dolorosa. The posterior roots were not 
degenerated and the origin of the fibres could not be traced, but as there was an 
alteration in the columns of Goll the fibres in the pia might arise from a regenerative 
process in the posterior roots. 
HE.xicu (1902) has placed the whole question of neuroma of the cord in a new 
light. In six cases of different affections of the cord he found formations similar to 
those described by Raymonp, Pick, and others. Nerve fibres with myelin sheath and 
sheath of Schwann could be traced in the adventitia of vessels from the periphery of 
the cord to the central canal vessels, whence they radiated into Clarke’s column. 
Here and there the fibres develop into nodules which, under a low power, appear. as 
