MULTIPLE NEUROMATA OF THE CENTRAL NERVOUS SYSTEM. 745 
axis-cylinders, and in 10 per cent. formalin solution with after-hardening in Miiller’s 
fluid for medullated sheaths. The paraffin sections were cut at 7u, and were stained 
with hematoxylin and eosin, Van Gieson’s stain, Heidenhain’s iron-hematoxylin, and 
Unna’s polychrome methylene-blue. Weigert’s elastic tissue and Mallory’s connective 
tissue stains were also used. The celloidin sections were stained with the Kulschitzky- 
Pal modification of Weigert’s medullated sheath stain, with Van Gieson’s stain, and 
with the Bielschowsky- Williamson axis-cylinder method. 
The following regions were examined in serial paraffin or celloidin sections :—the 
whole of the pons, medulla oblongata, the 7th and 8th cervical and 1st dorsal segments, 
and the whole lumbo-sacral cord. Portions from each of the remaining segments of 
the cord were prepared both for paraffin and celloidin : two segments in the upper and 
two in the lower dorsal regions being cut in serial longitudinal, frontal section. 
The preliminary investigation was confined entirely to the cord. Subsequently 
the medulla and pons were examined, and as the formations in these regions seemed at 
first sight essentially different from those in the cord, it is natural that the subject 
should be considered under the two headings: the one, the spinal cord; the other, 
medulla oblongata and pons. 
I.—Sprnau Corp. 
Enormous numbers of nodules of neuroma were found distributed in the cord 
substance throughout its whole length, except in the upper five cervical and in the 
2nd and 3rd dorsal segments. In those segments cut serially (7th cervical to Ist 
dorsal inclusive, and the lumbo-sacral), nodules could be traced in every preparation, 
often indeed numerous nodules in each section. All the remaining segments showed 
definite nodule formation or indications that such had existed. 
Throughout the whole of the spinal pia abnormal, medullated fibres were found. 
In the upper cervical region these were very scattered and cut mostly transversely, so 
that they appeared as fine dots bordering especially the outer layer of the pia. In the 
cervical enlargement and dorsal cord they became more numerous and strands of fine 
fibres could be traced, cut longitudinally or transversely, both in Van Gieson- and 
Weigert-stained preparations. In the lumbo-sacral cord the pia was infiltrated with 
fibres forming strands, tufts, and nodules. These were very markedly accumulated in 
the region of the anterior fissure and of the ligamentum denticulatum, and in the latter 
situation they formed frequently a nodule as large as the cross-section of the ligament 
itself. The pial fibres in the lumbo-sacral cord were so numerous that the whole 
circumference of the pia was seamed with strands of four to twelve fibres cut longitudin- 
ally, or obliquely, or transversely, and in the adventitia of the pial vessels they formed 
an encircling reticulum. It was specially noted that throughout the whole of the pia 
covering the posterior columns and in the posterior median septum there was scarcely any 
TRANS. ROY. SOC. EDIN., VOL. XLVIII. PART III. (NO. 27). 107 
