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MULTIPLE NEUROMATA OF THE CENTRAL NERVOUS SYSTEM. noo 
had been present, this segment was quite normal. The pia showed a few fibres cut 
transversely and obliquely, and there was a certain amount of infiltration of the pia 
and of the vessels of the cord, especially of the grey matter, with lymphocytic-like cells. 
In the upper part of the 7th cervical segment the nodule formation had already 
become much more evident. A large pear-shaped nodule was present in the centre of the 
anterior horn on one side: this extended through nearly twenty paraftin sections, and 
several of the vessels distributed in the grey matter show leashes of fine fibrils in their 
walls. Throughout both this and the next segment, almost every section showed beauti- 
fully that most of the vessels in the grey matter contained these delicate fibres. Figs. 
10-12 and 29-83 are all taken from these two segments, in which the nodule formation 
had taken place more in relation to the central than to the peripheral vessels. In the 
adventitia of the vessels, silver preparations revealed a fine plexus of fibres with 
numerous lateral branches and fine terminal bulbs or clubs (figs. 10, 12): only a few 
ring-forms could be traced. These appearances must be looked upon as equivalent to 
Cajal’s cénes and anneaux. When a vessel bends or divides, the leash of fibrils in 
its walls curves round or branches off along the two divisions (fig. 33). In relation to 
many of these nodules, the secondary fibrosis had involved specially that part of the 
anterior horn bordering the white matter. Weigert-stained preparations also showed 
that there was an involvement of the myelin of the intra-medullary anterior roots, but 
silver preparations brought out the integrity of the axis-cylinder (fig. 34). 
In the 1st dorsal segment, there was a return to the more normal architecture of 
the cord, with a few more or less isolated nodules and a commencing fibrosis involving 
the terminal ramifications of the fibres of the nodules. The 2nd and 8rd dorsal 
seoments were practically normal with the exception of the slight sclerosis to be noted 
later. 
The segments from the 4th dorsal to the 1st lumbar inclusive showed a very 
uniform change, uniform in character though not in degree. At numerous levels the 
only nodules present were found in the centre of the grey matter in the form of an 
extensive plexus round a vessel as its centre. In other sections, leashes of fibres could 
be traced from such nodules along all the vessels to the circumference of the grey 
matter—passing to anterior and lateral horns and to Clarke’s column. Even where 
the structure of the cord was retained, there was an indication of fibrosis in relation to 
the nodules, and as this advanced the nodule gradually disappeared, leaving only a few 
fine fibres around a vessel. Pial fibres are present, in limited numbers, around the 
whole lateral cord: and a few nodules could be traced in the pial septa. 
The lumbo-sacral cord proved to be a perfect store-house of neuromata. Nodules 
could be traced in every preparation without exception, and the histological picture, 
formed by the combined nodule formation, the accompanying fibrosis, the sclerosis, 
and the fibrosis of the intra-medullary course of the anterior and posterior roots, 
changes not only in every segment but in every section. Throughout this region the 
pia also was perfectly black, in Weigert-stained sections, with fibres cut longitudinally, 
