772 DR ALEXANDER BRUCE AND DR JAMES W. DAWSON ON 
become oblique. In all of these patches the normal framework of the tissues was 
preserved, with an enlargement of the glia cells in relation to the fibres: a change 
similar to that noted in relation to the nucleated patches internal to the posterior root- 
entry zone in the cord. Here, also, as in the cord, the nucleated fibres could never be, 
beyond doubt, found to end loosely in the tissue or break up into fusiform elements. 
Weigert preparations proved a degeneration of the fibres coincident with the nucleation, 
but adjoining Bielschowsky preparations proved the integrity of the axis-cylinders. 
Before leaving these changes in relation to sensory nerve paths, which we consider 
quite analogous to the changes in the posterior root-entry zone, it is necessary to add 
that a very exhaustive examination of serial sections of medulla and pons was made 
before the conclusion was arrived at that this change was limited to sensory strands. 
The only motor nerve root which showed changes at all comparable was the 3rd. 
The fibres of the oculo-motor nerve seemed to have a very extensive zone of exit— 
passing out from the surface in several widely separated strands, the outermost of which 
adjoined the crus. Several of these strands were nucleated, but only for a short 
distance, and the greater part of the change was analogous to that, to be described 
under (5), in connection with the motor nerve roots. 
(8) ParcHes composeD or InrERLAcING NUCLEATED FIBRES AND FUsIFORM 
NucLeateD HLEMENTS. 
The first impression received from a low power view of such a patch, if the attention 
be confined to the loose meshwork, is that we have a proliferation of young connective 
tissue cells, for this loose tissue is in intimate relation to dilated capillaries, which, with 
their walls composed of a single layer of endothelium, are very similar to new-formed 
vessels (59 and 61). A closer examination, however, shows that these cells differ in 
many respects from young fibroblasts, and that they bear a close resemblance to the 
spindle-shaped elements, derived from the proliferation of the sarcolemma nuclei and 
the increase of the sarcoplasm—young myoblasts—in the young granulation tissue 
between the two ends of a muscle wound, before the increasing condensation of the scar 
tissue has caused their atrophy and their transformation into connective-tissue-like 
elements. Such cells stam more homogeneously than fibroblasts, have not the same 
branching processes, and can for a time be readily distinguished from connective tissue 
cells and endothelial cells. 
Further, it is noted that these spindle-shaped nucleated elements link themselves 
on to one another in the most definite way (figs. 59 and 60), again just as endothelial 
cells in granulation tissue align themselves to form young capillaries. There is this 
difference, however, that this alignment is seldom in two parallel rows with a lumen 
between, but is an interlacing in very varied directions of linked elements, which only 
later converge, as it were, into strands composed of several nucleated cell-chains. From 
figs. 59 and 60 it can be seen that as these fusiform nucleated elements link themselves 
