ae a ee ene ees Cone 
MULTIPLE NEUROMATA OF THE CENTRAL NERVOUS SYSTEM. 775 
We desire to draw special attention to the photographs (figs. 59-66) which show 
beautifully the fusiform nucleated elements (figs. 59 and 60), their linking into cell-chains 
and the fusion of imbricated ends (figs. 60 and 65), the transition of the chains into 
nucleated bands (fig. 61), and the convergence of the bands into longitudinal strands 
(figs. 62 and 66), between which are found tubes cut transversely. 
(4) Nopute Formation wird CoNvoLUTED ARRANGEMENT OF- THE FIBRES. 
Such nodules were found in very few and isolated positions. The largest, composed 
of tortuous fibres with numerous nuclei, is represented in fig. 64, and was situated 
laterally and posteriorly to the strands of the 7th nerve and close to the floor of 
the 4th ventricle. It had developed in relation to one side of a medium-sized vessel, 
and when traced upwards divided into strands which passed along the two divisions of 
this vessel to form more or less large nodules in relation to each branch. In serial 
sections both the original nodule and the two smaller ones could be followed till the 
fibres unwound themselves from their compact disposition both at the upper and lower 
limits into tortuous but parallel fibres, which resolve into nucleated tubes, and then 
finally break up into interlacing fusiform nucleated elements. Within the fibres of the 
nodule, in iron-heematoxylin-fuchsin sections there is present a distinct central filament— 
the axis-cylinder, a continuous but faintly-staining myelin sheath, and, where the fibres 
ean be isolated, a distinct outer membrane staining pink. A small amount of inter- 
fibrillar connective tissue is also present, derived probably from the adventitia of the 
vessel. Fig. 5 shows the fibres of this nodule cut longitudinally for a short part of 
their course, with a structure very similar to that of a peripheral nerve: the nuclei, 
however, are larger and more numerous. 
If a dissociation of the fibres by an increase of the interfibrillar tissue takes place, 
as was found in a nodule lying near one inferior olivary nucleus, the fibres assume more 
the appearance of those of a peripheral nerve. In such fibres the fact that the nucleus 
—though peripheral—is still definitely within the lumen of the tube and is not applied 
to it from the outside as a connective-tissue nucleus, can be very beautifully recognised. 
In relation to all the nodules, similar in structure to that just described, there were 
found, in the immediately surrounding tissue, radiating lines, the structure of which 
was resolved into cell-chains and isolated fusiform cells which were undergoing a fibrous 
transformation. 
(5) Areas IN RELATION To THE SUPERFICIAL OricIN oF Motor Crantat NERVES. 
The earliest indication of such change was in the form of a proliferation of cells 
just within the pia, accompanied by a certain amount of fibrosis and degeneration of 
emerging fibres. This change was most marked in the emerging roots of the 
hypoglossal on both sides, These strands, with Weigert’s stain, show along their 
