CONCEBNING THE EFFECTS OF "TUBA" FISH-POISON. 137 



7. H. X. Eidley. Journal of Straits Medical Association, page 

 136, 1894. 



S. J. D. Gimlette. " Malay poisons and charm cures," page 91, 

 1915. 



9. Quoted by Eidley. Agricultural Bulletin, Straits Settlements, 

 page 218, 1898. 



(The author regrets that no reference has been made in the 

 above paper to Yan Hasselt's research published in the Archives in- 

 ternationales de Pharmacodynamic et Therapie, xxi. (1911) p. 243. 

 Information regarding the existence of Yan Hasselt's work was re- 

 ceived after the paper had gone to press) . 



Fig. 1. Monkey under chloroform anaesthesia. Effects on 

 respiration and blood pressure of injecting 1 c. c. 1 in 30 " tuba " 

 poison into the femoral vein. A. Eecord of respiration. B. 

 Blood pressure in femoral artery. C. Signal of injection. D. 

 Time in two seconds. Note that the respiration and blood pressure 

 are effected about forty seconds after the beginning of the injec- 

 tion. Eespiration is greatly affected and ceases eleven minutes 

 after the injection (Fig. I. X), thus producing death. The blood 

 pressure falls very considerably at first but recovers in a few 

 minutes, and is still well maintained when the respiration ceases. 

 The heart was felt beating after the respiration ceased. 



Fig. 2. A. Monkey under chloroform anaesthesia, vagi intact. 

 Effects on respiration and blood pressure of injecting ^ c. c. 1 in 

 100 " tuba " into the femoral vein. A. B. C. D. same readings as 

 in fig. 1. Eespiration is at first slightly augmented and later, 

 weakened. 



Fig. 2. B. Same animal as in fig. 2 A, out with vagi cut. 

 Effects on respiration and blood pressure of injecting 1 c. c. 1 in 

 100 " tuba " into the femoral vein. 



The respiration is similarly but more markedly affected in 

 fig. 2 B, than in fig. 2 A, a larger dose of the poison being in- 

 jected. The respiration recovers eventually. Note the fall of 

 blood pressure in both cases. In fig. 2 A, the heart beats are 

 just perceptible on the tracing. After cutting the vagi, Fig. 2 

 B, the heart beats are greatly augmented and the blood pressure is 

 Taised considerably, these results being the normal effects of cutting 

 the vagi. 



In this experiment death does not occur, because the dose of 

 poison administered is non-lethal. 



H. A. Soc, No. 73, 191( 



