FRANCIS.' CASES OF MORBID ANATOMY. 519 



decided cases of stricture and scirrhus of the pylorus, though, indeed, 

 the glandular structure of this part, in its most healthy state, must not 

 be overlooked as a concurring circumstance, favourable to the produc- 

 tion of affections of this kind, as remarked by Dr. Baillie ;* in which 

 opinion, however, he had long been anticipated by Horfman.f When, 

 the stomach has lost its tone, it is more particularly liable to disorders 

 of this alarming nature. The case of the late distinguished Dr. Peter 

 Middlcton, Professor of Medicine in King's College, is a memorable 

 example of this truth. Debility of the digestive organs, as I am in- 

 formed by the venerable Dr. Samuel Bard, preceded the formation of 

 the stricture and scirrhus of the pylorus, from which he died in January, 

 1781, after ten months' suffering. The particulars not long since made 

 public, by the late Doctor Ferriar of Manchester, of a case of un- 

 mixed scirrhus of the pylorus favours the same deduction ;J and in 

 another formidable instance of the same distressing complaint, which 

 was followed by considerable ulceration, as dissection proved, and which 

 occurred in the practice of Dr. Hosaek, in March last, frequent 

 attacks of diarrhoea, for a period of four years, prostrated the patient's 

 strength, and were among the precursors of the disease.? 



On the 4th of June, the present year, I examined the body of a 

 female subject, aged thirty-eight, who had died on the preceding day, 

 of a complication of distressing symptoms. Among other morbid 

 changes which were perceived, was a scirrhus of the pylorus, which 

 completely dosed the inferior passage of the stomach, and about which 



* Morbid Anatomy of the Human Body. 



f Medicin. System. Rational, torn. 3. 



\ Med. Hist, and Reflect, vol. 4. p. 111. 



\ See the Details in the present paper constituting the second case of Morbid Anatomy. 



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