156 C. J. MARTIN. 
on being drawn. Portal, splenic, mesenteric, 
and renal veins thrombosed. No urine in 
bladder. Examination of blood—-Hemo- 
globin in solution in the plasma. Extensive 
extravasation of blood in situation of inocu- 
lation. Hemorrhages in lungs and portal 
area, 
In this experiment the amount of poison injected was the same 
as formerly (Experiment 4). In this case however, the entire 
venom was introduced and the animal speedily succumbed from 
extensive intravascular clotting, whereas in the previous experi- 
ment he nearly died from respiratory paralysis, but ultimately 
made a speedy recovery. In the first experiment there were no 
symptoms indicating destruction of blood corpuscles, or hemor- 
rhages, whereas the post mortem following Experiment 6 demon” 
strated that both had occurred. 
I therefore conclude that Pseudechis venom contains at least 
two toxic proteids : 
(1) A proteid precipitated on heating the solution to 82° C. 
and indiffusible. 
(2) An albumose,' not precipitated by heat and diffusible. 
(3) And that the former is responsible for the destruction of 
blood corpuscles and hemorrhages, whereas the latter is 
principally a nerve-cell poison and is endowed with a 
selective affinity for those nerve-cells constituting the 
respiratory centre. 
If two poisons, one of which passes much more readily through 
the capillary wall than the other, be simultaneously injected into 
a connective tissue space, the former will reach the circulation 
_ more rapidly than the latter. Under such conditions the effect 
1 It is difficult to classify this proteid in any present system. It is not 
rendered insoluble in dilute saline solutions by prolonged sojourn _— 
absolute alcohol. This fact would point to its being an albumose. 
inability to pass through a film of gelatin, and coagulation on cee. 
would lead one to class it with the abumens or globulins. 
