ABvSTRACTS 
107 
1908] 
minutes, only one died apparently as a direct result of the ane- 
mia, but of twelve between the periods of seven minutes and eight 
and one half minutes, only one, after seven and one half minutes, 
recovered. The remaining dogs all died. 
After a resuscitation, the course of events in the animals which 
succumbed, while limited according to the extent of the reanima- 
tion, was similar to that in the dogs which did eventually recover. 
Many of the dogs showed more than a mere reflex revival there 
being some temporary manifestation of special senses and higher 
faculties in addition. In general, three stages were to be observed. 
A state of hyperexcitability followed reanimation, reaching its 
maximum in one to three hours, when retrogression began. This 
second stage was characterized by the onset of uncontrolled mus- 
cular movements, either coordinate or convulsive, lasted a longer 
time, and gradually passed into the third stage of depression and 
paralysis. The crisis in practically all the experiments was 
reached in from twelve to twenty-four hours. Then death quickly 
ensued or distinct improvement of nervous functions shortly 
began, continuing more or less rapidly till complete restoration, 
though the convalescent period lasted in two dogs four and six 
weeks respectively. There was no intermediate condition of fatal 
outcome delayed for several days except in several cases in which 
death was due to accidental organic lesion. Up to a certain point, 
not to be exactly limited, but roughly six minutes, the after 
effects were not marked, and the second, third, or fourth day 
brought complete recovery. Beyond the six minute limit, how- 
ever, there was a great deal of after effect, increasing out of all 
proportion to the increase in the duration of the period of anemia, 
reaching as well in the dogs which finally recovered a temporary 
state in which the animal was little more than a cardio-respira- 
tory mechanism. 
(The sequence of return of the various functions and reflexes 
and the special phenomena following a resuscitation are dis- 
cussed in detail . ) 
Histological examination both of presumptive recoveries and 
fatal cases was made by ordinary methods and those of Nissl and 
Marchi. The neurocytes of the fatal cases uniformly presented 
the greatest change, not merely chromolytie but here and there 
