PKINCIPAL PHYSIOLOGICAL TESTS, 



23 



has returned to normal in the cat, the substance has then disappeared 

 almost entirely from the blood. Elliott's table showing the effects 

 of injecting smaller doses gives the different results obtained: 



CAT (VAGI CUT). 



Time. 

 11.45. 



Treatment. 

 Received 0.18 mar. adrenalin. 



11.48. Received 0.30 ine\ adrenalin. 



11.56. 



12.05. 



Received 0.3 mg. adrenalin 



12.0S. 



Received 0.6 nig. adrenalin 



12.14. 



Received 0.6 mg. adrenalin 



12.22. 



Received 0.6 mg. adrenalin 



12.26. 





12.40. 



Received 1 mg. adrenalin. 



12.46. 



Received 1 mg. adrenalin. 



Results. 

 Blood pressure rose 150 to 220 



mm. Hg. 

 Blood pressure rose 130 to 230 



mm. Hg. 

 Blood contained no demonstrable 

 adrenalin. 



Blood pressure rose 145 to 220 

 mm. Hg. 



Blood pressure rose 110 to 210 



mm. Hg. 

 Blood pressure rose 130 to 220 



mm. Hg. 

 Blood pressure rose 120 to 206 



mm. Hg. 

 Blood contained no adrenalin. 



Blood 



rose 110 to 200 



140 to L 



12.50. 



1.17. Received 1 mar. adrenalin. 



1.21. Received 1 mg. adrenalin. 



1.24. 

 1.25. 



Received 1 ma;, adrenalin. 



1.45. Received 1 mg. adrenalin. 



1.48. 

 Control cat showed 0.01 ma;, in 5 c. c. 



pressure 



mm. Hg. 

 Blood pressure rose 



mm. Hg. 

 Pupils still dilated. Blood pres- 

 sure 150 mm. Hg. 

 Blood pressure rose 95 to 170 



mm. Hg. 

 Blood pressure rose 130 to 156 



mm. Hg. 

 Blood pressure 140; no rise. 

 Adrenalin found in blood. Five 



c. c. contained 0.02 mg. 

 Blood pressure rose 60 to 115 



mm. Hg. 

 No demonstrable adrenalin. 



In comparing the strengths of solutions it should be remembered 

 that because 1 c. c. of a solution gave a rise of 17 mm. Hg, 2 c. c. will 

 not necessarily double this rise; in fact, while there is a general 

 increase with increasing doses up to a certain limit, we are unable to 

 find any mathematical relationship between the rise in blood pressure 

 and the dose. Thus Toujan in a dog narcotized with chloralose and 

 atropinized (lcgm. per 7 kilos), injected 1 c. c. of a suprarenal extract 

 containing 0.001 mg. per cubic centimeter and obtained arise of 17 

 mm. After five-minute intervals — 



Injected 2 c. c. and obtained a rise of 19.5 mm. 

 Injected 3 c. c. and obtained a rise of 25.0 mm. 

 Injected 4 c. c. and obtained a rise of 23.0 mm. 

 Injected 5 c. c. and obtained a rise of 25.0 mm. 



112 



