22 SUPKAKENAL GLANDS. 



In cats under urethane, 0.03 mg. of adrenalin produced the maxi- 

 mum rise. 



Subcutaneous injections b or administration per os usually pro- 

 duced no rise in blood pressure. The slight rise seen at times may be 

 due to the local action on the stomach walls. Intramuscular inj ections 

 are ; however, followed by some rise, c and the effects vary with the 

 mode of injection as to whether it passes through the hepatic circu- 

 lation or through the muscles, etc/ 



II the injection of small doses is rapidly repeated the rise in blood 

 pressure with the same amount of active principle is slightly less but 

 more persistent. 6 With medium doses the rise and its duration may be 

 greater than from the first, but if a proper interval of time elapses 

 between the injections the second rise will correspond to the first, an 

 observation which is confirmed by Baylac/ For a dog of 8 kilos, five 

 minutes' time is sufficient when using small doses — 0.006 to 0.001 mg.^ 

 Josserand says there is no accumulation with 0.000016 mg. per kilo. ft 



If large doses are used, the pressure may stay high for a long time, 

 then fall below normal/' and serious disturbances with the heart, shown 

 by pericardial effusions, may occur and vitiate the results Weiss and 

 Harris k have claimed that adrenalin can still be found in the blood 

 even when the blood pressure has fallen to normal; thus after inject- 

 ing 0.0034 gram of adrenalin into a cat weighing 3,000 grams and 

 waiting thirty minutes, the transfused blood caused a rise of 15 mm. 

 in a second cat. No control experiments with normal blood seem to 

 have been made. Elliott, however, says that when the blood pressure 



a Elliott, T. R. Action of adrenalin. Jour. Physiol., vol. 32, p. 448, 1905. 

 & Reichert, E. T. Adrenalin. Univ. Pa. Med. Bui., vol. 14. p. 51, 1901. 

 c Meltzer, S. J., and Auer, J. Ueber d. Resorption aus den Muskeln. Zent. f. Phy- 

 siol., vol. 18, p. 689, 1904. 

 d Carnot, P., and Josserand, P. Des differences d'action de l'adrenaline sur la pres- 



sion sanguine suivant les voies de penetration. Comp. Rend. Hebd. Soc. de 



Biol., vol. 54, p. 1472, 1902. 

 e Toujan. G. Recherches exper. sur l'adrenaline. These, Toulouse, 1905, p. 37. 

 / Baylac, J. Recherches exper. sur le proprietes physiol. et toxique de l'adrenaline. 



Arch. Med. de Toulouse, vol. 12, p. 252, 1905. [Used 10-minute interval for 



rabbits.] 

 9 Toujan, G. Recherches exper. sur radrenaline. These, Toulouse, 1905, p. 38. 

 k Josserand, P. Contrib. a 1' etude physiol. de radrenaline. These, Paris, 1904, p. 33. 

 Note. — See also Gioffredi, C, La distruezione dell' adrenaline nell' organismo, 



Archiv. di Farmacol. Speriment. , vol. 6, pp. 127, 145, 1907. 

 ^Battelli, F. Transformation ■ de l'adrenaline dans l'organisnie. Compt. Rend. 



Hebd. Soc. de Biol., vol. 54, p. 1518, 1902. 

 J Elliott, T. R. Action of adrenalin. Jour. Physiol., vol. 32, p. 444, 1905. 

 £ Weiss, O., and Harris, J. Zerstorung des Adrenalins im lebenden Tier. Arch. f. 



Gesam. Physiol., vol. 103, p. 510, 1904. 

 Harris, J. Dissert., Konigsberg, 1904. 

 Battelli, F. Transformation de l'adrenaline dans l'organisme. Compt. Rend. 



Hebd. Soc. de Biol., vol. 54, p. 1519, 1902. 



112 



