PKINCIPAL PHYSIOLOGICAL TESTS. 21 



an intravenous injection of 1 c. c. of a 1-100,000 solution, Takamine 

 obtained a rise of 30 mm. Hg in the case of a dog weighing 8 kilos, 

 while in a dog weighing 15.5 kilos 0.000016 gram induced a rise 

 of 9 mm. a 



With a similar injection of 1 c. c. of a 1-10,000 solution, John 6 

 obtained a rise of 50 mm., registered by a Hurthle manometer, in a 

 dog weighing 3i kilos when the vagi were not cut. These results 

 remained constant on repeating. If one vagus nerve was cut the 

 pressure rose in one case 75 mm., and on repeating rose 60 mm. If 

 both nerves were cut the pressure rose much higher — about 150 mm. 



According to Toujan c 0.001 mg. of adrenalin will cause an appre- 

 ciable rise in atropinized dogs weighing 10 kilos, a sensibility of 

 1-1,000,000, and Sollmann reports a rise of 14 mm. after the injec- 

 tion of 0.001 mg. per kilo. Carnot and Josserand obtained a maxi- 

 mum rise of 17.5 cm. Hg in a dog weighing 15 kilos with 0.000016 

 gram per kilo of adrenalin. d 



A dog weighing 11.29 kilos ansesthetize'd with 0.3 gram of morphin 

 intravenously after an injection into the vein of 0.001 gram of adrenalin 

 gave a rise from 38 mm. normal to 128 mm. Hg. A second injec- 

 tion gave a rise from 36 mm. to 132 mm. e In Dupuis and Van den 

 Eeckhart's hands an intravenuos injection of 1 c. c. of a 1-4,000 solu- 

 tion of adrenalin increased the blood pressure in the femoral artery 

 4 cm. Hg in a dog weighing 23 kilos, under morphin and atropin. 

 This rise persisted 1 \ minutes. One c. c. of a 1-1,000 solution produced 

 a rise of 14 cm. This returned to normal in five minutes. The rise 

 was followed by a hypotension of 1 cm. below normal/ 



Sudden death may at times occur in dogs even from 0.12 mg. of 

 adrenalin, although the rise in blood pressure may have been only 

 small (32 mm.). In these cases the action seems to fall directly on 

 the heart, as the respiration may continue after the heart stops.^ 



a Takamine, J. Adrenalin, the active principle of the suprarenal glands. Amer. 



Jour. Pharm., vol. 73, p. 530, 1901; Therap. Gaz., vol. 25, p. 223, 1901. 

 & John, K. Nebennierenpraparate. Dissert., Leipzig, 1906, p. 17. 

 c Toujan, G. Recherches exper. sur l'adrenaline. These, Toulouse, 1905, p. 36. 

 d Carnot, P., and Josserand, P. Les differences d'action de l'adrenaline sur la pres- 



sion sanguine suivant les voies de penetration. Comp. Rend. Ilebd. Soc. de 



Biol., vol. 54, p. 1473, 1902. 

 « Reichert, E. T. Adrenalin, the active principle of adrenal extract. Univ. Pa. 



Med. Bui., vol. 14, p. 53, 1901. 

 / Dupuis and Van den Eeckhart. L'adrenaline. Ann. de Med. Vet., vol. 52, p. 484, 



1903. 

 Note . — Other figures may be found in Neujean, V. , Contrib. a 1' etude exper. de l'adre- 

 naline, Arch. Internat. de Pharmacodynamic, vol. 13, p. 45, 1904. 

 9 Elliott, T. R. Action of adrenalin. Jour. Physiol., vol. 32, p. 465, 1905. 

 Livon, C. Danger duprincipe actif des capsules surrenales dial yse. Comp. Rend. 



Hebd. Soc. de Biol., vol. 54, p. 1501, 1902. 



112 



