20 SUPRARENAL GLANDS. 



Epinephrin sulphate intravenously injected into atropinized dogs 

 previously narcotized with morphin and ether produced a rise as 

 follows : 



0.083 millionth of a gram per kilo body weight, 5 mm. Hg. 

 0.23 millionth of a gram per kilo body weight. 7 mm. Hg. 

 0.49 millionth of a gram per kilo body weight. 15 mm. Hg. 

 0.69 millionth of a gram per kilo body weight, 20 mm. Hg. 

 1.7 millionth of a gram per kilo body weight, 24 mm. Hg. 

 5.7 millionth of a gram per kilo body weight, 66 mm. Hg. 



Unfortunately, in these experiments the interval of time between 

 the injections is not specified. 



In a dog weighing 4.5 kilos with a carotid pressure of 140 mm. Hg 

 the intravenous injection of 0.02 mg. of adrenalin was followed by a 

 rise of 46 mm. After the injection of atropin the same dose caused 

 a rise of 50 mm. 6 



The normal blood pressure in rabbits as measured from the carotid 

 artery is about 90 mm. Hg, but varies from 80 to 100. 



Josue c noted that while frequently repeated intravenous injections 

 caused a permanent rise in blood pressure, yet these animals still 

 gave the characteristic abrupt rise in blood pressure on fresh injec- 

 tions — in other words, there was no immunity — and Elliott and 

 Durham in three experiments with cats failed to find the presence 

 of an anti-bo dy. c/ 



The normal blood pressure for dogs, as measured from the carotid 

 artery, is 140 mm. and in rabbits 70 mm. of mercury, 6 while the 

 maximum pressure according to Elliott is ±300 mm. for dogs, 

 ISO mm. for rabbits, and 240 mm. for cats. 



Oliver and Schaefer-^ have claimed that 0.015 gram per kilo of the 

 fresh glands would cause the maximum rise in dogs (10 kilos). 



In non-narcotized and non-curarized rabbits Pruszynski^ noted a 

 rise of 90 mm. Hg with 0.000047 gram per kilo of adrenalin. With 



a Hunt. R. On the effects of intravenous injections of minimal doses of epinephrin 

 sulphate upon the arterial blood pressure. Proc. Amer. Physiol. Soc, p. vii; 

 Amer. Jour. Physiol., vol. 5, 1901. 



b Baylac. J. Recherches exper. sur les proprietes physiol. et toxiques de Tadrenaline. 

 * Arch. Med. de Toulouse, vol. 12. p. 265. 1905. 



c Josue. 0. I/a pression arterielle chez le lapin a la suites d' injections repetees 

 d" adrenaline dans les veines. Comp. Rend. Hebd. Soc. de Biol., vol. 59. pt. 2, 

 p. 319. 1905. 



d Elliott. T. R., and Durham, H. E. On subcutaneous injections of adrenalin. 

 Jour. Physiol., vol. 34. p. 490. 1906. 



« Langendorff, 0. Physiolog. Graphik., p. 204. 



/ Oliver. G.. and Schaefer. E. A. Physiological effects of extracts of suprarenal cap- 

 sules. Jour. Physiol., vol. 18. p. 235, 1895. 



9 Pruszynski. J. Influence of adrenalin on the circulatory system. Medicine, vol. 

 11, p. 924. 1905. 



112 



