PKINCIPAL PHYSIOLOGICAL TESTS. 19 



tone has disadvantages, it is generally used for this class of work in 

 dogs where the animal is not allowed to recover (0.2 gram per kilo is 

 usually given in alcoholic solution after the hypodermic injection of 

 morphin, or chloretone may be used alone) . This does away with the 

 use of a volatile anaesthetic. After the use of large doses of chlore- 

 tone alone the writer noted that while the animal may be merely drowsy 

 after one hour, a few whiffs of ether will secure good anaesthesia, which 

 will continue. Sometimes as anaesthesia sets in the animal ceases to 

 breathe, but a few strokes of the respiration machine will soon restore 

 the breathing, which will then continue of itself. In the case of rab- 

 bits, 3 grams of ure thane may be given in solution by mouth, or 1.50 

 grams subcutaneously, 6 while cats should receive 1.25 grams per kilo. 

 With this anaesthetic and kept on a warm table, the blood pressure in 

 cats will remain at 130-140 mm. for hours. Urethane is not suitable 

 for dogs. Before connecting the animal to the kymograph it should 

 be weighed, so that the necessary dose of adrenalin can be calculated. 



Results obtained by various investigators. — Cameron d has shown that 

 the smallest dose which gives a "definite and invariable rise" in blood 

 pressure in rabbits weighing about 2,000 grams is 0.00062 mg., or 

 0.0003 mg. per kilo, or 0.00000031 gram per kilogram; that is, 0.5 c. c. 

 of a 0.125 per cent solution of an adrenalin solution of 1 to 1,000, 

 or 0.5 c. c. of a solution of 1 to 800,000 (1 c. c. of a 1-1,000 solution 

 diluted to 800 c. c). 



In cats, which are more resistant than rabbits, Ehrmann 6 found 

 that the intravenous injection of 0.1 mg. gave a rise which was just 

 appreciable. 



Abel's epinephrin bisulphate in 0.00013 gram caused a rise of 

 14 mm. Hg in a small dog with cut vagi/ and von Fiirth's suprarenin 

 iron compound in doses of 0.000017 gram per kilo (clog) caused the 

 maximum rise, while 0.000075 gram caused a marked rise, 24 mm. Hg 

 in rabbits (2 kilos) J* 



a Impens, E. Chloretone. Arch. Internat. cle Pharmacodynamic, vol. S, p. 77, 1901. 

 Houghton, E. M., and Aldrich, T. B. Chloretone. Jour. Amer. Med. Assoc, vol. 



33, p. 777, 1899. 

 & Schmiedeberg, 0. Ueber d. pharmakol. Wirkungen u. d. therap. Anwend. einiger 



Carbaminsaure-ester. Arch. f. Exper. Path., vol. 20, p. 203, 1886. 

 c Elliott, T. R. Action of adrenalin. Jour. Physiol. , vol. 32, p. 449, 1905. 

 d Cameron, I. D. On the methods of standardising suprarenal preparations. Proc. 



Roy. Soc. Edinburgh, vol. 26, p. 161, 1905. 

 e Ehrmann, R. Ueber eine physiol. Werthbestimmung des Adrenalins. Arch. f. 



Exp. Path. u. Pharmakol., vol. 53, p. 106, 1905. [Weight of animal not given.] 

 / Abel, J. J. Ueber d. blutdruckerregenden Bestandtheil der Nebenniere, das 



Epinephrin. Zeits. f. Physiol. Chem., vol. 28, p. 339, 1899. 

 0Von Fiirth, O. Zur Kenntniss d. brenzkatechinahnlich. Substanz d. Nebennieren. 



Zeits. f. Physiol. Chem., vol. 29, pp. 115 and 112, 1900. 



112 



