10 SUPRARENAL GLANDS. 



Von Furth a obtained a principle which he named suprarenin and 

 gave the formula C 5 H 9 N0 2 or C 5 H 7 N0 9 , but later changed this to 

 C 9 H 13 NO s . 



Takamine b simplified the method of isolation and made it commer- 

 cially available, giving his preparation the name adrenalin, with the 

 formula C 10 H 15 NO 3 . 



Simultaneous with Takamine's paper, Aldrich, Abel's former asso- 

 ciate, published his results. His body was evidently much purer than 

 Takamine's, as he purified before precipitating, but his method 

 was not commercially available on account of the necessary puri- 

 fication from the lead. Aldrich adopted Takamine's name adrenalin, 

 although his formula C 9 H 13 N0 3 differed by CH 2 from that of Taka- 

 mine. These two preparations are often confused. Aldrich pointed 

 out that if the benzoyl group was removed from Abel's original 

 formula, the resultant formula was close to his. All three investi- 

 gators — Abel, Takamine, and Aldrich — were dealing with the same 

 body, but in varying degrees of purity. 



Abel has compared the analytical data furnished by Aldrich and 

 Takamine, and declares that the analyses do not bear out the empir- 

 ical formulas deduced. d The formula of Aldrich has been corrobo- 

 rated by Bertrand in France, e and adopted by Pauly, von Furth, Stolz, 

 Abderhalden, and Bergell, in Germany/ The two latter investiga- 

 tors used Abel's purification method, but came to different conclu- 



a Von Furth, O. Zur Kenntniss d. brenzkatechinahnlich. Substanz in d. Nebennieren. 



Zeits. f. Physiol. Chemie, vol. 24, p. 142, 1898; vol. 26, p. 15, 1898-99; vol. 29, 



p. 105, 1900*. 



Zur Kenntniss des Suprarenins. Beitr. z. Chem. Phys. u. Path. , vol. 1, p. 243, 1902. 



Zur Kenntniss des Suprarenins (Adrenalins). Sitz. d. Kaiserl. Akad. d. Wissen. 



Wien, Math.-natur. Kl., vol. 112, pt. 3, 1903. 

 Zur Kenntniss des Suprarenins (Adrenalins). Monats. f. Chem., vol. 24, pp. 261- 

 290, 1903. 

 b Takamine, J. Adrenalin, the active principle of the suprarenal glands. Amer. Jour. 

 Pharm., vol. 73, p. 523, 1901. 

 The blood-pressure-raising principle of the suprarenal glands. Therap. Gaz., vol. 

 25, p. 221, 1901. 

 c Aldrich, T. B. Preliminary report on the active principle of the suprarenal gland. 

 Amer. Jour. Physiol., vol. 5, p. 457, 1901. 

 Adrenalin, the active principle of the suprarenal glands. Jour. Amer. Chem. 

 Soc, vol. 27, p. 1074, 1905. 

 d Abel, J. J. On epinephrin and its compounds. Amer. Jour. Pharm., vol. 75, p. 309, 



1903. 

 e Bertrand, G. Sur la composition chimique et la formule de l'adrenaline. Conip. 



Bend. Acad. d. Sci., vol. 139, p. 502, 1904. 

 /Pauly, H. Zur Kenntniss des Adrenalins. Ber. d. Deutsch. Chem. Gesells., vol. 36, 

 pt. 3, p. 2944, 1903; vol. 37, pt. 2, p. 1388, 1904. 

 Abderhalden, C, and Bergell, P. Zur Kenntniss d. Epinephrins. Ber. d. Deutsch. 

 Chem. Gesells., vol. 37, pt. 2, p. 2022, 1904. 

 TJeber d. Epinephrin. Munch. Med. Woch., vol. 51, p. 1003, 1904. 



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