18 MISCELLANEOUS PAPERS. 



minutes after the administration of the last dose of extract 14 c. c. 

 more were fed, emesis again resulting in about eight minutes, followed 

 about fifteen minutes later by further efforts toward elimination by 

 the intestines. Since in both dogs and, cats emesis is especially easy, 

 no especial significance is to be attached to that phase of the results. 

 No tremors resulted and the appetite remained as usual. 



In order to reduce the liability to emesis which may follow the 

 administration of large doses, smaller quantities of the extract were 

 given. If 7 c. c. of an extract concentrated to 32 c. c, representing a 

 dried plant residue of 39 grams, were fed, no emesis followed for three 

 hours. On taking a further dose of 8 c. c. the animal vomited within 

 ten minutes. However, five minutes after this, slight movements of 

 the skin could be seen, but these were apparently only such cutaneous 

 movements as are commonly observed in cats. After 6 c. c. more were 

 fed emesis soon followed. The same result followed the feeding of 11 

 c. c. after a period of about fifty minutes. 



During the course of feeding with Eupatorium extracts as above 

 indicated, the cat gained an ounce in weight in a week, showing nor- 

 mal appetite and evacuations. After four days more the weight 

 increased about 5-| ounces (155.8 grams). 



After a further interval of two weeks without treatment, when a 

 concentrated extract representing 35 grains of plant was fed. no 

 tremors or other abnormal symptoms were to be noted, although the 

 animal was kept under careful observation. When, on the day fol- 

 lowing, an extract representing 65 grams was given no symptoms 

 whatever followed other than evidence of a somewhat laxative action, 

 and the cat continued to increase in weight. This animal gained 219 

 grams during the month it was kept under observation. ' 



EFFECT OF WHITE SXAKEROOT ON DOGSl 



An extract of Eupatorium representing 23 grams of the dried 

 plant preserved in chloroform when fed to a dog kept under careful 

 observation produced no symptoms, and the appetite remained nor- 

 mal; temperature before feeding, 100.6° F. When, twelve days later, 

 a concentrated aqueous extract representing 200 grams of dried plant 

 was given to the same dog. weighing 14: pounds 12 ounces (6,690.1 

 grams), having a temperature before feeding of 101° F., no symp- 

 toms resulted, the temperature after one and one-half hours register- 

 ing 102° F. Xo symptoms appeared during observation for three 

 more days, the weight increasing to 15 pounds 5 J ounces (6,959.8 

 grams). Eleven days later the weight increased to 16 pounds 15 

 ounces (7,682.7 grams). The animal was very playful throughout 

 the investigation. 



121—1 



