154 C. J. MARTIN. 
exhibited no ameeboid movements. At the end of this time # 
nuclei in some of them were very distinct, as if fixed by 
swell and their outlines to grow less distinct until they disappeared, 
leaving a small heap of granules to mark their grave. D 
this time, control specimens situated under similar circumstane 
showed no change, and the leucocytes were exhibiting acti 
amceboid movements. 
The action of the poison on the corpuscles of pigeon’s bood 
similar to the above, but the dissolution of the red cells, ' 
poison of this concentration proceeds more slowly. 
The blood corpuscles of different mammals present remarkable 
diversity in their power of resisting the destructive effects of 
venom. Dog’s blood is much more sensitive to this action of the 
venom than that of any other animal I have experimented Wi : 
The readiness with which the corpuscles of this animal aré 
troyed approaches that of the frog. 
Some idea of the small quantity of venom which is neces 
to determine the destruction of the red corpuscles of dogs m 
gathered from the fact that if 1 c.c. of fresh defibrinated blot 
be mixed with an equal volume of ‘9% NaCl solution con tal 
"0000002 gramme of venom, and allowed to stand for four hou 
at the temperature of the laboratory (15° C.) the serum w 
covers the corpuscles becomes deeply stained with haemo 
and if a little of the sediment be examined under the mic 
numbers of crystals of haemoglobin are to be seen, togeth' 
Some corpuscles. A control specimen under similar circums 
except that the salt solution contained no venom, showed 
corpuscles to be well preserved and the serum was only § 
tinged with haemoglobin. 
If the concentration of venom in the solution be im 
the blood be kept at body temperature, the haemoglobin 
out much more readily, and in a few hours no corpuscles 
found. 
