156 c. J. MARTIN. 
As I shall presently point out the same extensive destruction 
of corpuscles occurs when the venom is injected into dogs | 
quantities of -0001 gramme per kilogramme of the animal’s weight 
or even less. The lowest limit of concentration necessary to r0- 
duce this destruction is about the same both within the body 3 
in vitro, viz.:—-00001 gramme of venom per 100 C.C. of blood! 
The corpuscles of rabbits, guinea-pigs, cats, and white rats: ae 
my own blood, even when this was kept at body temperature 
When the strength of the venom was increased much beyond this 
amount, disintegration of corpuscles occurred, but proceeded slowly. 
The disparity in the amount of blood destruction following 
injection of the venom into animals of different species, products 
a corresponding variation in symptoms, and is associated with 
marked difference in their susceptibility to the occurrence of 
intravascular clotting. Dogs are, weight for weight, about ten 
times as sensitive to this action of the poison as any other mammal 
with which I have experimented, 
(6)—Ezxamination of the blood of animals after the injection Y 
venom. 
The injection of much above a minimum fatal dose of ve 
produces some destruction of red corpuscles in every animal 
which I have experimented. When dogs are the animals 
however, destruction of red corpuscles is very considerable & 
with one-fifth a minimum fatal dose, and the escaped haemog 
presents the same increased tendency to crystallize as I have 
cribed to be the case in vitro, The haemoglobin crystallizes 
within the body. The urine nearly always contains such 
and on three occasions an animal has died two or three days 
the injection of the poison with suppression of urine, and ! 
Raa nea ey iE 
_ =o at this conclusion I have assumed that on 
animal’s weight consisted of blood.—(Welcker) 
