160 C. J. MARTIN. 
(4) It occurs to a trifling extent only, when the poison is 
cutaneously injected. 
Sherrington! pointed out that most of the substances which 
when intravenously injected occasion marked leucocytopenia 
also lymphagogues. Bayliss and Starling? demonstrated 
lymph flow was a function of capillary blood pressure and 
the latter depends much more upon venous than on the arterial 
pressure in the region concerned. The injection of venom intot 
circulation produces an immediate diminution of blood flow, 
low arterial and high venous pressures, and it appears to me 
improbable that such a condition of diminished flow together WI 
high pressure, is accompanied by greatly increased diapedesisa 
corresponding decrease of circulating leucocytes. If the animal 
continues to live, the arterial blood pressure, after an interval of 
a few minutes, steadily rises and the number of leucocytes in the 
blood concurrently increases. A mechanical - explanation 
however, insufficient, for the introduction of fine particles 
carmine produces no alteration in the circulation, but is never: 
theless the cause of the collection of leucocytes in internal organs. 
The experiments form two series: (1) In which the venom ™ 
introduced directly into a vein; and (2) In which the venom ™ 
injected subcutaneously. 
Enumeration of the corpuscles was accomplished in the follo’ 
way :—0°5c.c. of blood just withdrawn from an artery, was 
up in a carefully graduated pipette and mixed with 99°5 c.c. 
8% solution of MgSO, slightly tinged with methy! violet. 
drops of the mixture were placed in the cell of a haemocyt® 
and the red corpuscles in ten squares and the leo 
hundred squares of the instrument, counted by two 0D® 
The numbers counted by each observer usually agreed ie 
and the numbers given in the protocols are the means ns 
1 Proc. Roy. Soc - Lond., tv., p. 197. 
2 Journ. of Physiol. xvr., 1894. 
3 The number of corpuscles in ten squares multiplied by ten tl 
gives the number in one cubic millimetre of blood. a 
