168 C. J. MARTIN. 
compared by Wooldridge,' who first separated it from stromata, 
to the substance found by Plosz in liver cells, and named by 
nucleo-albumen. Wooldridge refers to this body as—* 
Eiweisskérper der mit einem anderen an phosphor reichen moleeil 
verbunden ist.” He came to this conclusion from the fact tha 
by digesting this body with gastric juice, peptone, and a phosphor 
ous-containing body which he compares with Miescher’s nuclei, 
were formed. 
It would be an unwarrantable assumption to suppose that when 
venom is injected into the blood stream, it produces precisely the 
same decomposition in the stromata as can be effected by extract 
ing blood corpuscles with ether, alcohol and sodium chloride 
solution outside the body. Nevertheless we have evidence, as will 
be seen shortly, that bodies of the nature of nucleo-albumens are, 
under these conditions the part result, and that some of the 
changes which the plasma undergoes, after the introduction 
snake venom into the circulation, are to be attributed to the 
presence of these particular products of the disintegration of the 
red corpuscles. : oe 
Effect on the coagulability of dog’s blood. 
In the general enquiry, I have frequently had occasion to Us 
such methods as are commonly employed for obtaining grap! 
records of the blood pressure in arteries and veins, and have P 
struck with the remarkably satisfactory manner in which 
blood has behaved as regards clotting. On more than one 00 
a tracing of the venous pressure in.a dog has continued for 
hours, without coagulation occurring in the cannula. : 
This behaviour suggested some inhibition of the normal clot 
power of extravascular blood. During several experiments, 
accordingly drew samples of blood. In all of these coast 
was retarded, the specimens clotting only after the lapse of - 
to twenty hours, or not at all. At this time I was working ¥ as 
1 Du Bois Reymond’s Archiv. 1881, p. 387- 
