174 C. J. MARTIN. 
Professor Wright has recently extended his observations an 
shown that it is the increase in CO, and not the diminution! 
the contained oxygen, which determines the greater tendency t 
coagulate which occurs in venous blood.! 
(2) Influence of Digestion. : 
I find I have records of eleven experiments in which 0-0002 
gramme per kilo. was injected into the jugular vein of ado 
Seven of these animals died within eight minutes, from extensite 
venous and arterial thrombosis. Three others died within two 
hours, and one lived for upwards of four hours. The post mortél 
examination of this last animal discovered no intravascular clotting 
and the shed blood remained fluid until it putrefied. In the three 
which lived from one to two hours after the injection, there a 
more or less thrombosis of the portal venous system, but the 
from the rest of the body remained fluid for several hours. 
These experiments were not performed with the sole object af 
observing the effect of venom on the clotting of the blood, aul 
every one of them records, including one of arterial blood press 
were taken on a kymograph. Consequently I have in each cas 
the exact time and duration of the injection to refer £95 Inal 
the experiments the above mentioned amount per 
dissolved in 2 c.c. of a7 7% solution of NaCl, and the time occup 
by the injection, as registered on the tracing, was from five 
eight seconds. ‘The importance of the knowledge that the F 
injection was fairly constant, I shall discuss later on. 
At the time of these experiments I attributed the variation 
results to idiosyncracies in the dogs. On reconsidering the ma ; 
however, I am inclined to attribute them to the effect of ¢ di 
The seven first mentioned experiments were performed i ine 
and the four last also in sequence. During the former 
was working in the afternoon, whilst the experiments form 
latter series were performed in the forenoon, and I find that 
dogs have always been fed at 11 a.m. Thus, for the first’ 
1 Proc. Roy. Soc. Lond., Vol. Lv. 
