184 C. J. MARTIN. 
of clotting power is due to the absence of free calcium salts from 
the blood. 
The analogous behaviour of blood after snake venom snjootia ? 
with peptone blood, is not however, in this respect departed from; 
for I find that both peptone plasma and the plasma obtained after 
the slow injection of nucleo-albumens, behave in a manner 
identical with snake venom plasma, provided a sufficient quantity 
of these bodies have been introduced to produce a complete 
disappearance of all tendency to spontaneous coagulation. As 
Pekelharing’s inviting hypothesis only explains the partial 
phenomena of peptone injection, one cannot accept it as an inter- 
pretation of the facts. 7 
Significance of these phenomena. 
These phenomena of intravascular coagulation exhibiting 
positive and negative phases, together with the conditions W. 
I have found to modify the result, show the closest parallelism 
with the effects observed by Wooldridge, Wright?and Halliburton! 
to follow the introduction of tissue-fibrinogen (nucleoalbune) 
into the circulation. This parallelism is still further evident when 
one compares the behaviour of the fluid blood, drawn from 
animal poisoned with venom, in which the negative phase is pre 
1 “On intravase. coag.”—Proc. Roy. Soc., 1886. “ Ueber intra’ 
Gerinnung ”—Du Bois Reymond’s Arch. 1886. is poate a 
der Blutgerinnung ”—Ludwig’s Veatackerift, 1887. ‘On he 
Infarction of the Liver”—Proc. Path. Soc. 1837. ‘‘ The Nata 
Coagulation ”—Hainsworth & ee! London 1888. “ Ueber Schutaimh 
= chemischem Wege ’—Du Bois Reymond’s Arch. 1888. 
“On the conditions which determine the distribution of = c0 
ie following the intravascular injection of Woo ldridge § 
fibrinogen.” —Journal of Physiol., Vol. xm., No.2. “A na 
fibrinogen.”—Proc. Roy. Irish Acad., 3rd Series, Vol. 1, i 
tissue or cell fibrinogen in its relation to the pathology ‘a 
Lancet, Feb. 27 and March 5, 1892. Vo 
3 “ . . . 3° of Ph: peer a 
The proteids of kidney and liver cells. —Journal 
ee —— Number. “The chem. physiol. of the a 
Goulstonian Lectures, lecture 3, B.M.J., March 25, 189 
