186 C. J. MARTIN. 
of the thrombosis, and Wright,!in following up the researches of — 
this observer, has very considerably extended our knowledge in 
this respect, as regards both dogs and other animals. 
One of the modifying conditions observed by Wooldridge was 
that in fasting dogs, unless large quantities of the “ tissue 
fibrinogen ” were injected, the intravascular clotting was limited 
to the portal area ; whereas the same dose given to an animal in — 
full digestion produced clotting extending to the general venous — 
system, right heart, and even into the arteries. I have shown — 
reasons for believing that the blood of animals in full digestion 
exhibits the same increased sensitiveness towards the action of 
the venom. om 
Ihave previously had occasion to mention an experiment of : 
Wright's, in which he rendered an animal dyspneic by compressioa 
of the trachea before injecting tissue-fibrinogen. Wright fount 
that the injection of an amount of “ tissue-fibrinogen ” which 
would, in an animal not so treated, give rise to clotting only in : 
the portal venous system, under these circumstances followed by 
intravascular clotting throughout the whole vascular system. 
Similar experiments with venom produced results corresponding, 
in every case, with those detailed by Wright. | 
Another experimental condition which influences in an eX 
corresponding manner the results from injections of both “ iss 
fibrinogen” and venom, is the rapidity with which they 
introduced into the circulation. Wright! has already drav 
attention to this factor as influencing the results from the inj 
of “tissue-fibrinogen.” I have experimented with “tissue 
fibrinogen” in order to determine this point, and I find that 
I have indicated to be the case with vénom, one can produce § 
will the positive or negative phase by the injection of the s# 
amount of “tissue-fibrinogen,” simply by varying the - 
which it is allowed to enter the circulation. Both “Hee® 
1 Loc. cit. 
1 Proc, Roy. Irish Acad., 3rd Series, Vol. 11., No. 2. 
