272 C. J. MARTIN. 
On two occasions I have seen some rather interesting patho- 
logical changes in the liver following injection of the poison, 
Wooldridge, in 1888, described some changes in the liver, which 
he had obtained by producing thrombosis of the portal vein 
through the injection of nucleo-albumens (tissue-fibrinogen). If 
the animal was killed a few days after the injection, a clot was 
found in the portal vein, and the liver showed more or les 
extensive infarctions. When examined after a fortnight, the clot 
in the portal vein had completely disappeared, and to the naked 
eye there was no trace of the hemorrhages, but microscopical 
examination revealed scattered patches of early cirrhosis of 4 
greater or less extent. 
Precisely the same result occasionally follows the injection of 
venom. ‘Two dogs which were killed by a second subcutaneous 
injection of poison fourteen days and twenty days respectively 
after they had received the first, both showed interstitial cirrhosis 
of the liver. I was not certain at the time of the first injection, 
that the portal veins of these dogs had been thrombosed. Such 
an event is, however a not uncommon occurrence in dogs after the 
injection of the poison. There was unmistakable evidence that 
hemorrhages had occurred in the liver, as the sections showed 
quantities of altered blood pigment. The pigment was intra 
cellular, and was scattered through the lobules, but was present 
in greatest amount at their external margins. I think, from the 
remarkable analogy between these experiments and those of 
Wooldridge, one may safely conclude that the portal veins had — ; 
been thrombosed. The dogs were very ill for two days and passed 
bloody urine, and in one of them a large quantity of blood- 
stained mucous escaped per rectum. They were both apparently 
well on the fourth day, and the urine was normal again 0? eg 
sixth, 
There is some evidence to show that cobra poison “ae 
the kidneys. Iam not yet satisfied that this is the case ™ 
his method 
Pseudechis poison, but my experiments so far, point to t 
1 Trans. Path. Soc., Lond. 1888. 
