— 171 — 



accompanied by the usual symptoms: violent psychical excitation, delirium, 

 attacks of distress, passing amblyopy, increased pulse, toxic breathing, 

 paresthesia and dull headache. A noticeable symptom was a slight relapse 

 after 10 days, accompanied by myocarditis. The symptoms in the second 

 case were similar: convulsions difficult to overcome, increased rapidity of 

 breathing and pulse, extinction of the reflexes of pupils and conjunctiva. 

 In spite of medical aid the child died of collapse in the course of a few 

 hours. 



From the investigations of Lutz and Oudin 1 ) into the pharmacological 

 action of the various apiols' 2 ), J. Chevalier 3 ) draws conclusions which Lutz 4 ) 

 regards as inaccurate. It would take us too far to go into the details of 

 this controversy, for which we refer to the original papers. 



When 3 sulphur-atoms are introduced into the methylene-group in 

 ^-position of linalylacetate 5 ), a compound C12H20O2S3, known as linalyl- 

 acetate thiozonide, is formed. R. Knorr 6 ) reports on the employment of this 

 body in gynaecological practice. For the preparation of linalylacetate thi- 

 ozonide, oils were employed of a definite and determinable linalylacetate 

 content. The thiozonide was dissolved in alkaline thiozonate and the resul- 

 tant product, called "thilavene", which contained 0,65% sulphur in organic, 

 and from 4 to 4,5°/ sulphur in anorganic combination, was used medici- 

 nally. Knorr employed it in baths and also, in the form of thilavene- 

 glycerol, for vaginal tampons, his experience being that thilavene acted 

 at least as efficaciously as, and usually even more so than, the older 

 sulphur-preparations. 



On the pharmacological action of Dutch Myrtle oil and samphire oil, 

 see under these headings. 



PhytO'physiological Notes. 



The theory that the formation of glucosides in living plants is due to 

 the action of enzymes has been confirmed by a paper published by 

 Ciamician and Ravenna 7 ). Indian corn and other plants, finely crushed, 

 were left for two months in flasks with aqueous solutions of salicin, 

 saligenin, pyrocatechol, hydroquinone, and benzaldehyde cyanohydrin, to- 



J ) Comp. Report October 1909, 163. 



2 ) "Various apiols" refers to the commercial products, not to the isomerides. 



3 ) Bull. d. Sciences pharmacol. 17 (1910), 128. 



J ) Ibidem 209; quoted from Chem. Zentralbl. 1910, I. 34. 



5 ) Comp. Report April 1909, 115. 



6 ) Med. Klinik 1910, 669; quoted from Apotheker Ztg. 25 (1910), 323. 



') Rendiconti della R. Accademia dei Lincei (5), 18 (1910), II. 549; quoted from Chem. 

 Zentralbl. 1910, I. 935. 



