— 131 — 



body of this class, viz., anisol. In 24 distillations he obtained from 

 60 gm. anisol 20 gm. distillate, in which were found about 9 gm. 

 unconverted anisol, about 3 gm. benzene, 3 gm. phenol, and 2,5 gm. 

 diphenyl. Of the volatile products of distillation, benzene was retained 

 as p-dibrombenzene and ethylene as dibromide, by means of a receiver 

 charged with bromine. It follows that the stability of phenol ethers 

 in the distillation with zinc dust is but slight. 



After a short historical review of the publications dealing with 

 nitrosocarvacrol, E. Kremers and J. W. Br and el 1 ) devote a detailed 

 study to the various methods now in use for producing this prepar- 

 ation. During a series of experiments made with a view to deter- 

 mining the molecular weights of nitrosocarvacrol and nitrosothymol by 

 the boiling point method, Kremers and Brand el found that the mole- 

 cular weight ascertained gives different values according to the nature 

 of the solvent (alcohol, chloroform, or benzene) and the degree of 

 concentration of the solutions. From the results the general conclusion 

 may apparently be drawn, that in the case of the nitroso-derivatives 

 of thymol and carvacrol a tendency exists to form double molecules 

 in solution, but that such a tendency is only in one instance approxi- 

 mately satisfied, namely in the case of benzene. 



By adding silver nitrate to the neutral solution of nitrosocarvacrol 

 in sodium hydroxide, Kremers and Br an del 2 ) obtained two silver 

 compounds of nitrosocarvacrol, C 10 H 12 NOAg and C 10 H 11 NOAg 2 . 



By allowing nitrous acid to act on myristicin, E. Rimini 3 ) endeav- 

 ours to bring further support to the view (already confirmed by Thorns) 

 that myristicin contains an allyl side- chain. The nitrosite formed in 

 the first instance, C 8 H 7 3 C 3 H 5 • N 2 3 , is converted by treatment 

 with absolute alcohol into a nitro-oxime C 8 H 7 3 • CH 2 • C(NOH) • 

 CH 2 N0 2 , from which the nitroketone is regenerated by boiling with 

 sulphuric acid. The presence of the nitro -group is proved by the capa- 

 city of being reduced into a ketone-amine which is identified by the 

 picrate. When treated with mercuric acetate according to Balbiano's 

 method, myristicin yields the following compound: 



/HgC 2 H 3 2 



CH 2 2 .(OCH 3 )C 6 H 2 .C 3 H 5 ( 



In the opinion of the author, this compound is very suitable for 

 the production of myristicin in the pure state. 



*) Pharmaceut. Review 22 (1904), 248. 

 *) Pharmaceut. Review 22 (1904), 290. 

 3 ) Rendiconti della Societa Chimica di Roma 2 (1904), 20. 



9* 



