— 146 — 



sufficiently long the cinnameine-values are too low. This is confirmed by 

 Lehmann and Mtiller, who have found that the best method of correcting 

 this error is not to add the liquor until the balsam alone has been shaken 

 with ether for some time. 



The addition of tragacanth as a clarifier is much to be recommended, 

 but a smaller quantity than that stated by Fromme (Annual Report of 

 the firm of Cassar § Loretz, Halle a. S., 1909) will suffice. This agrees 

 with our experience. 



Lehmann and Muller regard it as preferable to carry out the entire 

 cinnameine-determination volumetrically, and for this purpose they give 

 the following prescription: — 



To 2,5 g. Peru balsam add 5 g. water, shake, add a weighed quantity 

 of 30 g. ether and shake the mixture for one minute. Add 5 g. soda liquor, 

 again shake for 1 minute, leave standing for about 10 minutes and then 

 carefully pour off the layer of water until only about 3 cc. is left. Next 

 add 0,5 tragacanth and shake vigorously. After from 3 to 5 minutes, pour 

 the principal quantity of the ether-solution (25 to 28 g.) into a wide-necked 

 small flask, which, together with the cover, has been carefully tared, and 

 determine the weight of the ether-solution. When the ether has evaporated 

 in the water-bath the viscous cinnameine residue is dried for from 30 to 

 45 minutes at about 100°, allowed to cool in the desiccator and weighed. 



If, with 2,5 g. Peru balsam and 30 g. ether, the quantity of ethereal 

 cinnameine solution used up in the experiment equals = a grams, and if, 

 after evaporation of the ether, these are found to have yielded b grams 

 cinnameine, the percentage of cinnameine-content in the Peru balsam is 

 ascertainable by the following formula: — 



1200-6 

 a — b 



We may further state, although the fact is self-evident, that when 

 a cinnameine-estimation is carried out according to the German Pharma- 

 copoeia, Ed. V, care should be taken that the temperature throughout the 

 experiment is as equal as possible, as the volume of the ether-layer is 

 subject to fairly considerable changes as a result of alterations in tem- 

 perature. 



Pollantin. As stated in our last Report (p. 114), our new Pollantin 

 salve has been favourably received by the great majority of patients tq 

 whom we have sent samples with a request to give the article a trial/ 

 According to medical reports the percentage of patients whose condition 

 was considerably ameliorated by the use of this ointment was 53, that of 

 patients showing a partial improvement 32, and that of patients who failed 

 to obtain relief from the remedy 15. The new preparation, which is sup- 

 plied in the same manner as are our other Pollantin-preparations, has been 



