— 105 — 



depression which the water causes in the ethylene bromide must be 

 deducted from the depressions obtained. 



Physical notes. 



We have before us a work by Th. M. Lowry 1 ) on dynamic 

 isomerism in camphor halogen derivatives, and one by him 

 and H. Magson jointly on dynamic isomerism in sulphonic 

 acid derivatives of camphor. The experiments of these two authors 

 form a continuation of those of F. S. Kipping 2 ) who succeeded in 

 demonstrating that the sulphonic acids of a-chloro and a-bromo 

 camphor, as well as the simple halogen derivatives themselves, yield 

 isomerides. Now while Kip ping's experiments throw light on the 

 chemical side of these processes, in Lowry's and Mag son's work 

 the physical side of the bodies to be examined is brought more to the 

 foreground. The substances examined were a- and /?-bromo camphor 

 and a-chloro camphor, a-, /?-, and a, jz-dibromo camphor, a-, /?-, and 

 a, rc-chloro bromo camphor. The solubilities were determined by 

 evaporating weighed quantities of saturated solutions in weighing- 

 vessels. The specific gravity was determined by means of a self- 

 constructed graduated pipette. The determination of the rotatory 

 power was accomplished in a polarisation apparatus graduated to read 

 down to 0,00 1 °. The proportionate quantities in which the isomerides 

 are in equilibrium in the solution were measured, and finally the rapidity of 

 the isomeric change ascertained. With regard to dynamic occurrences of 

 isomerism in sulphonic derivatives of camphor, there were examined first 

 the derivatives of camphor jz-sulphonic acid, and subsequently those of 

 camphor /?-sulphonic acid, and of the latter the potassium salts, the amides 

 and anhydramides, the anilides and piperidides. The method of examin- 

 ation is analogous to that of the halogen derivatives of camphor. 



Pharmacologicophysiological notes. 



From A. J. J. Vandevelde 3 ) has appeared a III. communication 

 on the determination of the toxic action of chemical com- 

 pounds by haematolysis. The work comprises the determination of the 

 toxic ratio of various so-called "etherols" (Athrole)*), higher alcohols, etc. 

 which were treated similarly to previous objects of examination 5 ). We 

 would mention, among others, terpineol, clove oil, peppermint "etherol", 

 eucalyptus "etherol", lavender oil, lemon oil, etc. The experiments 

 showed that the "etherols" are not more poisonous than ordinary 

 essential oils. The toxicity increases with the number of carbon atoms. 



*) Journ. chem. Soc. 89 (1906), 1033, 1042. 



2 ) Proceed. Chem. Soc. 21 (1905), 124, 125. 



3 ) Chem.-Zeitg. 30 (1906), 296. 



4 ) Comp. Pharm. Centralh. 46 (1905), 818. * ?. X 

 6 ) Comp. Report April 1906, 103. 



