— no — 



beyond the OH -group in the nucleus, or which in certain places 

 have pure alkyl groups, possess the astringent action of tannin. In 

 these cases the irritating action due to the presence of the phenol-rest 

 is so slight, that it is not able to affect, in the alkaline intestine, the 

 astringent action of the tannin components. The advantage of these 

 derivatives over tannin is, however, due to this, that owing to their in- 

 solubility in acids they have no influence on the stomach, and on the 

 other hand, thanks to the phenol components, are capable of developing 

 in the intestine a special antiseptic action. 



In view of his experience, Hildebrandt considers the thymol 

 derivative of tannin as the most suitable substance for practical pur- 

 poses, the more so, as thymol itself is the most harmless of all phenols, 

 and has proved valuable for internal administration as an intestinal 

 disinfectant and against certain intestinal parasites. 



This preparation is manufactured by us, and placed on the market 

 under the name Tannothymal (m. p. about 235 ). It is a yellowish- 

 white to reddish powder, and is specially characterised by the fact that 

 without impairing the astringent action of tannin, it is almost tasteless; 

 that on the one hand, owing to its insolubility in acids, it does not 

 cause any trouble whatever to the stomach, and on the other, is 

 capable of being dissolved and split up in the alkaline intestinal juice, 

 where the antiseptic thymol action can then develop. It is scarcely 

 soluble in water, more readily in alcohol. In spite of the ready 

 solubility of the difficultly resorbed compound in alkali, only a small 

 proportion of the tannothymal administered internally enters into the 

 general circulation, as was proved by the examination of the urine, 

 so that the action can continue through the entire intestinal canal. 



Tannothymal was tested by O. Baumgarten 1 ), Privatdocent at the 

 University of Halle, with regard to its action in diarrhoea and intestinal 

 catarrh. It was found to be an extremely reliable intestinal astringent 

 in particularly obstinate cases, in which every other medication (tannigen, 

 tannalbin, tannin and opium) failed, and it had at the same time a 

 considerable antiseptic and a striking desodorising effect. The dose of 

 tannothymal for adults is 1 g., to be taken in one dose, in case of 

 need several times daily, for children proportionately less; in sick-fund 

 practice it may be prescribed in quantities of a knife-point's to a 

 tea-spoon full, three or more times daily. 



Free samples of this new preparation and also literature are at 

 all times at the disposal of medical practitioners. 



Thiosinamine. Hagenbach-Burckhardt 2 ) reports on two 

 cases in which cicatricial strictures of the oesophagus were cured by 



*) Munch, mediz. Wochenschr. 54 (1907), 1220; Klinisch-therap. Wochenschr. 

 1907, no. 28. 



2 ) Mediz. Klinik 3 (1907), Nr. 27. 



