— 125 — 



/CH 2 .CH 2 /CH 2 .CH 2 



CH,.CH ^>CH.CH(CH 3 ) 2 — > CH 3 .CH \cW- CH(CHg) 2 

 x CH 9 .C0 CH -C 



HO OH 



/CH 2 .CH 2 



-> CH 3 .CH \CH:C(CH 3 ) 2 . 



\CH 2 -CHO 



In the neutralized aqueous-alcoholic solution there was present the 

 sodium salt of an acid (from ioo g, menthone 10,7 g.) which boiled 

 at 17 mm. pressure between 149 and 158 , at ordinary pressure from 

 249 to 2 5 2°. On analysis it proved to be a decylic acid, probably 

 formed according to the formulae: — 



/CIVCH, +Hg0 

 CH 3 -CH ^CH.CH(CH 3 ) 2 > COOH.CH 2 .CH.CH 2 .CH 2 .CH 2 .CH(CH 3 ),. 



\CH 2 .C0" ^ 



Pharmacologico-physiological notes. 



In the same manner as Witt's theory has established the 

 relations between the chemical constitution and the dyeing pro- 

 perties of bodies, it has been attempted to explain the relationship 

 between chemical constitution and odour. During the last few years, 

 research has turned to the study of the relations existing between 

 constitution and pharmacological action, and has found a number 

 of analogies and laws. The results obtained up the present have 

 been summarised in a uniform manner by H. Hildebrandt, Privat- 

 docent at the University of Halle, in a work now in the press: 

 Neuere Arzneimittel. Auf Grund von Studien iiber Be- 

 ziehungen zwischen chemischer Konstitution und pharma- 

 kologischer Wirkung unter Beriicksichtigung der synthetisch 

 hergestellten Arzneimittel (Modern pharmaceutical remedies. On 

 the strength of studies on the relations between chemical con- 

 stitution and pharmacological action, with regard to the synthetically- 

 produced pharmaceutical remedies). (Leipzig, 1907, Akad. Ver- 

 lagsgesellschaft.) After a short discussion of the difference in the 

 action exerted biologically and pharmacologically by bodies chemi- 

 cally identical but differing physically, and by chemically isomeric, 

 closely allied substances, the author turns to the discussion of the 

 physiologico-chemical processes on which the action of the substances 

 introduced into the organism is based, the influence of substitution, 

 isomerism, and also the introduction of certain atomic groups. 

 The following are dealt with in detail: the entry of atomic groups in 



