— 138 — ( 



alcohol, and camphenilol, the tertiary alcohols A-santenol and camphene 

 hydrate and the divalent terpin yield corresponding combined glucuronic 

 acids. But as a result of secondary processes other bodies may be 

 generated, as for instance in the case of thujyl alcohol, which is converted 

 by hydration into j9-menthane-diol-2,4. With sabinol, also, hydration is not 

 improbable. 



The behaviour of camphenilone is interesting. It is hydroxylised by 

 reduction and in this reaction behaves like the aliphatic ketones, whereas 

 the other terpene ketones which have so far been tested are either oxidised 

 or, like thujone, undergo great alteration. Camphenilone is eliminated in 

 the form of camphenilol glucuronic acid; menthone is probably oxidised into 

 the tertiary ketonic alcohol 4-hydroxymenthone, thujone yiels ^-menthane- 

 2-one-4-ol-glucuronic acid, and santenol gives rise to the keto alcohol 

 santenonol. 



Highly interesting are the observations of Hamalainen on the behaviour 

 of racemic bodies in the organism. In contradistinction to camphor and 

 borneol, the ^-component of camphenilone, camphenilol and santenone 

 combines with glucuronic acid to a greater extent, than does the cor- 

 responding optical antipode. 



A considerable number of the substances tested by Hamalainen have 

 been placed at his disposal by our firm. 



As demonstrated by experiments on cats, dogs, and rabbits 1 ), the 

 first effect of the introduction of camphor into the animal circulation is 

 to inflate the pulmonary cells, followed by an inflation of the cells of 

 the whole circulatory system. This results in a diminution of the pressure 

 in the right valve of the heart. These processes may acquire special 

 importance when the respiratory course within the lungs is somewhat 

 narrowed and the blood-pressure has been reduced. This explains the 

 favourable action of the continued camphor -treatment in pulmonary 

 tuberculosis. 



The toxicity of turpentine oil is dealt with on p. 110. 



On the pharmacological action of cineol see p. 120. 



PhytO'physiological Notes. 



In our Report of April 1911, p. 160, we referred to the interesting 

 publication by Curtius and Franzen on the occurrence of a,/?-hexylenic 

 aldehyde in the leaves of certain plants. Since that time a detailed paper 



*) E. Liebmann, Arch. f. exp. Pathol, u. Pharmak. 68 (1912), 59. Quoted from Chem. 

 Zentralhl. 1912, II. 46. 



