— H3 — 



Harries and Majima 1 ) showed "exaltation", Bruhl expresses the 

 surmise that it is in the well-known faculty of rearrangement of the 

 cyclic unsaturated hydrocarbons that the cause must be sought of the 

 anomalies which have been observed. He furthermore extends his 

 theoretical speculations to recent publications by Auwers and Hesse- 

 land 2 ) and also by Zelinsky and Gorsky 3 ). We cannot go into 

 details on the subject here; suffice it to state that in the case of 

 aliphatic compounds through the conjugation of the ethenoid - groups 

 an "exaltation" of molecular refraction and molecular dispersion was 

 invariably observed, the conjugations increasing in number in an 

 ascending degree. According to Bruhl the molecular dispersion in 

 particular is a prominent criterion of the constitution. 



Pharmaco-Physiological Notes. 



E. Rimini and F. Delitala 4 ) have carried out pharmacological 

 researches with safrol, myristicin, apiol, and asaron and with their 

 corresponding propenyl combinations and ^-nitro-derivatives. All these 

 combinations acted upon the central nervous system of cold-blooded 

 as well as of warm-blooded animals. In the case of the former, small 

 doses of the allyl and propenyl combinations had a marked narcotic 

 effect, while the /?-nitroderivatives provoked a characteristic condition 

 of muscular rigidity. Larger doses produced increasing symptoms of 

 paralysis, ending in death. The allyl combinations had the strongest, 

 the /?-nitro-derivatives the weakest, toxic effects; the propenyl combi- 

 nations stood midway between these two. Safrol possessed the greatest 

 toxicity, /?-nitro isoapiol the smallest. These differences in behaviour 

 are to be explained by the greater or less absorbability of the sub- 

 stances concerned. In the case of warm-blooded animals internal 

 administration produced vomiting. When hypodermically administered, 

 the liquid substances produced acute, and the solid substances chronic, 

 intoxication, followed in both cases by fatal results. We are unable to 

 enter into details of the investigations here, and for these we refer 

 to the original paper. 



J. H£mal&inen 5 ) has made experiments on the action of d-, r- 

 and 1-camphor on the heart of the frog, which showed that ail three 

 of these modifications were almost without effect upon that organ, of 



x ) Berl. Berichte 41 (1908), 2516; Report November 1908, 175. 



2 ) Berl. Berichte 41 (1908), 1819. 



3 ) Ibidem 2479, 2630. 



4 ) Archivio di Farmacologia e Terapeutica 14 (1908), 295. From a copy 

 kindly sent to us. 



5 ) Skandinavisches Archiv fur Physiologie 21 (1908), 64. We quote from a 

 copy kindly sent to us. 



