- 136 - 



of umbellulone in a sealed tube, which has now been carried out by 

 Semmler, is evidence of the correctness of that investigator's statement 

 as to the constitution of umbellulone. 



Phenols and Phenol-Ethers. 



In his dissertation 1 ), of which a copy was courteously sent to us, 

 C. Guillaumin describes ortho and parathymol. 



CH Q 



CH 



l 



3 



CH 



1 



n 



1 



■As 





1 



A 





\/ 



i 



— OH 



1 



-c/ c 



i 



CH 



/ \ 



CH, C 



Ho 



OH 



P- 



Thymol 



-OH 



:h * l_ c / CH 3 



H X CH 3 



o -Thymol 



m-Thymol (ordinary) 



For the preparation of para-thymol, para-thymol methyl ether 

 (prepared from pseudo-allylcresol methyl ether and sodium in alcoholic 

 solution), was treated in acetic acid solution according to Stormer's 

 method with hydrobromic acid. Ortho-thymol is prepared in precisely 

 the same manner. 



Para-thymol occurs in long, colourless needles, m. p, 3 6°, b. p. 

 228 to 229 (com, at 760 mm. press.), doo 0,9954, di 7j8 o 0,9817, 

 n Bi7 8° I >5 2 438- The odour of para-thymol is less pronounced than 

 that of ordinary thymol, and reminds of para-cresol. 



Ortho-thymol was not obtained in crystalline form; it appears as 

 a colourless liquid, b. p. 225 to 2 2 6° (com, at 760 mm. press.), 

 d o 0,9986, d 15)2 o 0,9865, n m5j20 1,52385. 



After giving a list of the literature existing on the pharmacological 

 behaviour of thymol, the author compares this behaviour with that 

 of the new isomers. 



With regard to toxicity, experiments on rabbits gave the follow- 

 ing results: — 



The fatal dose per kilo rabbit was: — 



0,033 g- f° r ordinary thymol; 

 0,036 g. for p-thymol; 

 0,045 g. for o-thymol. 



*) C. Guillaumin, Etude chimique et pharmacologique des thymols synthe- 

 tiques derives des acides cresotiniques. Paris 1909. 



