^6 Report of Schimmel 8j Co. 1921. 



some time to acquire a fatal vapour concentration, but with which the effects then 

 persist for longer periods; possibly also ethyl benzoate. Many aromatic and aliphatic 

 hydrocarbons, as well as phenols, salicylaldehyde, eucalyptole and q/c/ohexane, act 

 quickly asphyxiating; but they lose their efficiency already with weak aeration. 

 Eugenol is one of the remedies which act quickly and which retain their effect for a 

 long time, even with strong aeration. Of the esters of aliphatic acids, ethyl formate 

 is especially effective. On the other hand, there is among the esters of the aromatic 

 acids not a single one which approaches these compounds in their asphyxiating power. 

 Relatively most favourable are ethyl benzoate and methyl salicylate (wintergreen oil). 

 Among the hydroaromatic substances and terpenes, none were found which, applied 

 in small proportions, asphyxiated or killed the lice at once. The effects of compounds 

 of this group were very heterogeneous like those of the essential oils. It is noteworthy 

 that eucalyptole killed lice after 30 minutes and that pinene, carvene and thymene, but 

 not camphene, had a relatively-strong influence. Of terpene alcohols linalool was alone 

 active; of aldehydes and ketones, citronellal, citral, and carvone and fenchone were 

 moderately effective. Cyclohexane and phenyl mustard oil (phenylethyl mustard oil?) 

 proved somewhat stronger. The oils of anise, eucalyptus, fennel, origanum, turpentine, 

 peppermint and wintergreen oil killed the lice within 60 to 120 minutes. 



The volatile oils have a relaxing effect upon plain muscles, inhibiting their move- 

 ments. According to J. W. C. Gunn 1 ) this phenomenon would explain the carminative 

 action of these oils. The other effects of the essential oils upon the gastro-internal 

 tract are explained by local irritation and the reflexes arising from it, possibly also 

 by acceleration of the absorption. 



Ketocineole. — According to G. Cusmano 2 ), ketocineole, contrary to camphor which it 

 resembles in its constitution, does not stimulate the central nervous system, but causes 

 a depression of the cerebral activity. Especially in the experiments made with frogs the 

 initial action of camphor, reminding of curare, was missing in the case of ketocineole. 



A. Fuchs 3 ) has injected supersan (menthol-eucalyptol mixture) 4 ) in about 200 cases 

 of influenza, once or twice daily, in doses of one or two cc, intramuscularly. He 

 observed a very favourable influence upon the bronchial-catarrh phenomena (facilitated 

 secretion, copious phlegm), especially with early application of the remedy. 



As regards the use of benzyl alcohol for curing toothache, compare p. 52 of this Report. 



As regards the use of benzyl benzoate in medicine, cf. p. 52 of this Report. 



As regards the use of camphor in medicine, cf. p. 59 of this Report. 



With respect to oil of peppermint as remedy against cholelithiasis, cf. p. 33 of this Report. 



As regards poisonous symptoms caused by the partaking of oil of turpentine, cf. p. 48 

 of this Report. 



With respect to injections of the ethyl and methyl ethers of thymol, cf. p. 72 of this Report. 



As regards the use of cinnamic aldehyde in the treatment of lupus /md scrofulous 

 glands, cf. p. 60 of this Report. 





x ) Journ. Pharm. and exp. Therapeutics 16 (1920), 39; from Chem. Zentralbl. 1920, III. 804. — ») Gazz. 

 <;him. ital. 49 (1919), II. 228; from Chem. Zentralbl. 1920, III. 259. — 3 ) Munch, med. Wochenschr. 1920, 1018; 

 from Therap. Halbmonatsh. 34 (1920), 610. — *) Report April 1915, 77. 



