er re ls ~—a,, Sutra 
124 _ REPORT OF SCHIMMEL & Co. APRIL 1914. 
(C 8,058), in ethyl ether + 11,519 (C 8,035), in borneol ++ 11,35° (C 8,015), in carbon 
disulphide ++ 8,73° (C8,73) and in isopentane ++ 8,12° (C 8,011), whereas nopinone as 
such gave a) -+ 11,51°. 
Elsewhere, Tchugaeff, in collaboration with W. Pastanogoff’), has published a paper 
on the abnormal rotatory dispersion of coloured compounds. As a result of experi- 
ments with esters of /-menthyl, J-bornyl and D,J-fenchyl xanthogenic acid, they arrive 
at the conclusion that the susceptibility to temperature of the rotatory dispersion con- 
stitutes an eminently-marked property of active compounds. In the case of those 
compounds which have been examined this property depends not only upon the 
absorbing (suiphuretted) atomic complex, but also upon the character of the radical of 
the xanthogenate-group. 
In conclusion we may allude in a few words to a paper by Tchugaeff and 
A. Glebko’) on the principle of optical superposition set up by van ’t Hoff. : 
The authors combined the ethylesters of d- and /-tartaric acid as well as of meso- 
tartaric acid with /-menthyl or D-l-fenchylisocyanate respectively, and ascertained to 
what extent the rotation of the urethanes thus obtained corresponded to the theoretical 
requirements. In the course of these tests the results were found to correspond, at 
any rate approximately, with the requirements of the principle of optical superposition. 
With the object of gaining an insight into certain physical calculations of particular 
isomeric compounds of the sesquiterpene series, F.W. Semmler and Feldstein*) have 
prepared a number of primary substances of the terpene series, namely nopinane, 
6-dihydrolimonene, carane, dihydroterpinolene, and tanacetane, and have determined 
the values for Mp, Mg and Me of these hydrocarbons. They took as their starting 
point nopinone, dihydrocarvone, carone, pulegone, and tanacetone, heated these 
substances in a retort with hydrazine hydrate and so obtained the hydrazones, and ® 
converted the latter by treatment with sodium ethylate in a sealed tube into the 
hydrocarbons. The characters of these hydrocarbons are as follow: — 
Mp 
B. p. Np ap found calc. 
Nopinane ... . 149° (747 mm.) d==0,8611 14614414 +0° — — 
6-Dihydrolimonene 168 to 169° (750mm.) d=¢0,8217 1,45673 =+-0° 45,71 45,72 
Dihydroterpinolene 169 to 170° (748mm.) di50,8189 1,45823 — 46,00 45,72 
Tanacetane. . . . 156t0157°(747mm.) d”20,8158 1,44121 — 44,69 44,02 
@rrae. fe, 49 to 50° (9 mm.) d2°0,8381  1,45823 —34° 44,95 44,02 
As a result of these investigations, Semmler and Feldstein believe that they have 
proved that the increments which are observed in molecules with tricyclic rings, are 
not attributable to the adjacent position of a keto-group or other group, but to the 
tricyclic ring itself. 
: a 
5 
i 
Pharmaco-physiological Notes. 
We referred on p. 138 of our last October Report to the formation and properties 
of a series of terpene alcohol glucosides described by J. Hamalainen. In connection 
with this reference we may now make mention of the biological oxidation of certain 
glucosides, and of the place and mood of formation of the combined glucuronic acids © 
1) Zeitschr. f. physik. Chem. 85 (1913), 553. — %) Berl. Berichte 46 (1913), 2752. — 3) Berl. Berichte 40 — 
(1914), 384. “ 
