NOTES ON SCIENTIFIC RESEARCH. 141 
_ optical rotation. When water is abstracted from a mixture of these acids by treatment 
with acetyl chloride, /-bornylene-2-carboxylic acid (m.p. 115°) is formed. This body 
is capable of being hydrogenated by means of hydrogen, in the presence of palladium 
and gum arabic, into /-camphane-2-carboxylic acid (m. p. 78 to 80°). Houben and 
Kesselkaul*) had already previously prepared epicamphane-2-carboxylic acid from pinene 
hydrochloride by converting the latter into the magnesium compound and treating 
with carbon dioxide. Houben called this acid hydropinenecarboxylic acid. Zelinsky”) 
also has already handled this acid, which he described as camphane carboxylic acid. 
l-Bornylene-2-methyl carboxylate reacts readily with hydroxylamine in the presence 
of sodium methylate, giving rise to /-bornylene-2-hydroxamic acid. The latter yields 
d-camphor when heated with hydrochloric acid and distilled by steam. 
From the above it is clear that it is possible to convert d-camphor into /-epicamphor, 
and vice-versa, according to the following arrangement: — 
Sule trae d-Camphor ages nehd Labatt 
d-Camphocarboxylic acid l-Bornylene-2-hydroxamic acid 
d-Borneolcarboxylic acid l-Bornylene-2-carboxylic acid 
d-Bornylene-3-carboxylic acid l-Epiborneolcarboxylic acid 
d-Bornylene-3-hydroxamic acid l-Epicamphocarboxylic acid 
. Epicampher 2 
There remains to be mentioned the physiological action of epicamphor, which is 
decidedly weaker than that of its isomeride. About four times as much epicamphor 
as common camphor is required to produce an equal degree of acceleration of cardiac 
activity, while moreover the action of the epicamphor is much less sustained. In the 
same concentration which is required to produce a favourable effect with epicamphor, 
- common camphor provokes toxic symptoms. 
Fenchone. M. Saizeff*), when acting with zinc upon a mixture of fenchone and 
allyl iodide in the cold, obtained allyl fenchyl alcohol, a body which boils between 
107 and 109° at diminished pressure. d=> 0,9597; [a]p + 12,449; np 1,40143. When 
hydrochloric acid was passed into it, the allyl fenchyl alcohol yielded a body C,;He: Cl, 
b.p.122 to 124. 
Thujone. A few years ago we reported on a paper on alkylated thujones 
published by A. Haller*). Recently the same author has described new alkyl-derivatives 
of thujone and isothujone®). He set out from the consideration that if the formule 
assigned to thujone (I) and isothujone (II) H.C-CH-CH 
are correct, thujone must be trebly and C H3C-CH-CHs 
isothujone doubly alkylatable, and he has YN CGH 
in fact succeeded in preparing a triallyl- 5h Ces ale Hec-c CH 
thujone and a dimethylisothujone. The a | / | co ae | | : 
isothujone is much more difficult to alkylate Nt HeGoG = tCo 
than the thujone, and forms a considerable CH: CH, 
proportion of resin during the process. (I) Thujone. (II) Zsothujone. 
1) Berl. Berichte 85 (1902), 3996; 88 (1905), 3796; Report April 1906, 116. — 2) Berl. Berichte 85 (1902), 
4417. — Journ. russ. phys. chem. Ges. 84 (1902), 646. — *) Journ. russ. phys. chem. Ges. 40 (1913), 1578; Chem. 
Zentralbl. 1914, 1. 783. — 4) Compt. rend. 140 (1905), 1626; Report October 1905, 115. — 5). Compt. rend. 
157 (1913), 965. 
