7 
SCIENTIFIC AND OTHER NOTES ON ESSENTIAL OILS. 35 
obtained as a by-product only. Little importance need be attached to the melting 
point of rose oil, for by altering the process of distillation it is possible to produce’ 
rose oils of different melting points. 
According to Revillet’) the labourers engaged in the rose crop at the Riviera 
suffer from diseases of the skin of their hands every winter. Some of the symptoms 
are of an eczema-like nature and are produced by the various insecticides used in 
the rose plantations. Others are the result of infection by horse manure which is 
chiefly used by the growers. Finally the hands may get injured by coming in contact 
with the thorns, or small thorns may be left embedded in the skin. These often cause 
Suppuration, especially with beginners; labourers who have worked in the rose fields 
for some years appear to acquire a certain amount of immunity. Revillet has never 
observed cases of tetanus, but a few cases of botryomycosis which have most likely 
to be attributed to infection by horse manure. Revillet advises the workmen to wash 
their hands well after their work is done, and to remove all the thorns that may have 
penetrated the skin; wounds or abrasions should be treated with tincture of iodine. 
Santolina Oil. On page 41 of our previous Report we pointed out that according to 
L. Francesconi and N. Granata «-santolinenone is a racemic body, the hydroxylamino- 
oxime of which may be split into the optical antipodes by means of d-camphor sulphonic 
acid. Though the separation has not been completed so far, the authors, in collaboration 
with A. Sanna?) have now published a few particulars. The d-camphor sulphonate of 
the /-hydroxylamino-oxime of «-santolinenone melts at 192 to 196°; . [@]) — 20.35 °. 
The /-hydroxylamino-oxime of the «-santolinenone melts at 171°; [«], — 115.7°. 
Similar results were obtained with d-bromocamphor sulphonic acid. 
Francesconi and Granata*) consider a closer examination of the hydroxylamino- 
oxime as being of special interest for the elucidation of the structure of ¢-santolinenone. 
When treating this compound with dilute acids, the expected ketone 
was not obtained; the hydroxylamino-oxime behaves in a manner ate 
analogous to pulegone hydroxylamino-oxime (compare page 82 of Cc 
this Report). From the abnormal refraction values and from the We 
behaviour of the hydroxylamino derivatives in comparison with those AC CO 
from pulegone the authors deduce the correctness of the con- ea CH, 
Stitution formula adopted by them for «-santolinenone. TE 
When heating «-santolinenone hydroxylamino-oxime in alcoholic CH 
solution, «-santolinenone amino-oxime (m. p. 155°) and «-santolinenone H3C- CH: CHs 
dioxime (m. p. 200°) were formed. When boiling the hydroxylamino- 
oxime with alcohol and mercuric oxide, a larger yield of dioxime 
is obtained. On continued boiling with dilute hydrochloric acid, «-santolinonene 
hydroxylamino-oxime forms a compound CioHieN>2 (a nitrilimine?) of the m.p. 119 to 
120° and «-santolinenone imino-oxime (m.p. 169 to 172°). The latter compound is 
not always produced. It happens occasionally that in its place «-santolinenone imine 
is obtained. 
a-Santolinenone. 
Solidago Oil. The great Compositae genus of Solidago is represented in the United 
States by no less than 75 species, very few of which have been treated phytochemically. 
1) Lyon Medical; Répertoire 26 (1914), 360; Pharmaceutical Journ. 94 (1915), 287. — *) Gazz. chim. ital. 44 
(1914), Il. 354; Chem. Zentralbl. 1915, 1. 788. — *) Gazz. chim. ttal. 45 (1915), I. 167; Chem. Zentralbl. 1915, I. 1313. 
d 
3% 
