a 
( oc oceur in genuine ‘chenopodium oil, it was a clear case of 
 — It is oneeS o. see in Saat ME cae tone nay, mean manner the faker is aor 
to | proceed, not even stopping at gross adulteration of oils used exclusively for medicinal 
“purposes. As the odour of the oil is familiar to but few buyers and as the simple 
_ determination of the constants is in most cases no absolute guarantee for the quality 
of the oil such unscrupulous actions may remain undetected frequently enough; all 
" the more reason why such conduct should be pilloried. 
7 R. L. Levy*) as well as Bishop and Wilson?) reper on the treatment of anky- — 
_ lostomiasis and hook-worm disease. 
_ Levy gives the following indications as regards StGideione. treatment in adults: 
ist. day: liquid diet, a saline aperient in the morning. 2"4- day: breakfast and dinner 
are omitted. Saline aperient to be taken at 5 a.m., at 7, 9 and 12 o’clock 16 drops of 
_chenopodium oil each time, taken on a teaspoonful of pounded sugar. At 1 p.m. one oz. 
E of castor oil with the addition of 3 ccm. of chloroform. Dinner consisting of slops. 
The author £ompiles the cases of poisoning known so far in table-form. The majority 
of such cases were children and in nearly every instance an overdose of the remedy 
_ may be suspected. At any rate he recommends American wormseed oil as an efficient, 
_ cheap and, in therapeutical dosage, a non-poisonous remedy against ankylostomiasis. 
3 Bishop and Wilson, who prescribe chenopodium oil against hook-worm disease, 
- also recommend a dose of castor oil after wormseed-oil. They have found American 
3 _ wormseed oil to be much more efficient than thymol. 
We may here point out that we have reported on several occasions on the treat- 
Ement of worm diseases with American wormseed oil). 
On page 42/43 of our Report October 1915 we discussed a paper < W. Salant 
and E. K. Nelson on the effect of American wormseed oil. Further particulars on the 
_ physiological properties of this oil are now published by Salant in collaboration with 
_A. E. Livingston*). They found that intravenous injections of 0.02 to 0.085 cc. of 
chenopodium oil per kilo weight caused a reduction of blood pressure with dogs, cats, 
and rabbits; recovery takes place gradually, after 15 minutes. A second injection of 
the same amount produces a stronger effect, but if the administration be increased to 
0.2 ce. per kilo, no disturbance of the circulation is noticeable. This is fore especially. 
pronounced with dogs, less so with cats, and not at all with rabbits. The reduced 
blood pressure is due to the heart, the kidney volume being decreased along with the 
depression of blood pressure. Cardiac action is reduced after administration of cheno- 
‘podium oil, the same may be said of the excitability of the vagus. Chenopodium oil 
also seems to interfere with respiration; smaller amplitude and reduced activity with — 
breathlessness are likewise a consequence of chenopodium oil. Cats show this effect 
more quickly than dogs. With rabbits small doses seem to accelerate respiration and 
even after big doses breathlessness is rarely observed. - Even after intravenous in- 
jection of 0.02 to 0.024 cc. per kilo or administration of 2 g. per kilo in the stomach 
or the small intestine of the cat neither methemoglobin nor hemolysis occurred. 
‘It is surmised that the cause of slackened respiration and breathlessness is due to 
1) Journ. Americ. Med. Assoc. 63 (1914), 1946; Therap. Monatsh. 29 (1915), 633. — %) Journ. Americ. 
Med. Assoc. 65 (1916), 19; Chemist and Druggist 87 (1915), 767. — 3) See Report October 1906, 81; April 
1907, 102; April 1910, 121; October 1910, 143; April 1911, 121; October 1913, 108; April 1914, 99; April 1915, 
30. — *) Amer. Journ. Physiol. 88 (1915), 67; Chem, Zentralbl. 1915, I. 1082. 
* f 
