10 MISC. PUBLICATION 7 9, U. S. DEPT. OF AGRICULTURE 



TETRACHLORETHYLENE AND MAGNESIUM SULPHATE 



Tetrachlorethylene in doses of 10 c. c. with magnesium sulphate, 

 and in doses of 20 c. c. with magnesium sulphate, was less than 1 

 per cent effective against thornheads and only about 4.5 per cent 

 effective against ascarids. These doses are less than those of carbon 

 tetrachloride in these tests, and it is possible that tetrachlorethylene 

 in higher doses might show some efficacy where smaller doses have 

 failed. The evidence to date indicates that tetrachlorethylene is 

 probably a safer drug for use in some animals than is carbon tetra- 

 chloride. It is possible, therefore, that larger doses may be given 

 with safety to swine. Additional tests with this drug are needed to 

 determine the largest safe dose. 



KAMALA 



Kamala in a dose of 14 grams to one pig failed to remove any 

 thornheads or ascarids. Kamala, like male fern, is a taeniacide. A 

 kamala extract made by adding 45 grams of the drug to 96 c. c. of 

 carbon tetrachloride and allowing it to stand 48 hours, was IT per 

 cent effective against thornheads and 100 per cent effective against 

 ascarids. In another test a kamala extract made by adding 56 grams 

 of the drug to 130 c. c. of carbon tetrachloride and allowing it to 

 stand 48 hours, failed to remove any thornheads from one pig. The 

 kamala in this combination apparently reduced the efficacy of carbon 

 tetrachloride. 



NICOTINE SULPHATE 



A 1.5 per cent solution of 40 per cent nicotine sulphate in doses 

 of 120 c. c, preceded by a purgative, given to each of two pigs, was, 

 respectively, 33.3 per cent and 4.5 per cent effective for thornheads, 

 and in one pig, was 25 per cent effective against ascarids. The com- 

 bination of nicotine sulphate and carbon tetrachloride, which was 

 100 per cent effective against thornheads, appears to derive some 

 efficacy from both carbon tetrachloride and nicotine sulphate. This 

 mixture deserves further test. A solution of 40 per cent nicotine 

 sulphate combined with a 1 per cent solution of copper sulphate is 

 an effective remedy for stomach worms {Haemonclius contortus), 

 hookworms, and tapeworms of sheep, and nicotine sulphate com- 

 bined with a selected fuller's earth is used for the removal of As- 

 caridia from poultry. 



IODINE SOLUTION 



A hyperactive iodine solution given to one pig in a dose of 120 c. c. 

 failed to remove any thornheads. While it is not advisable to con- 

 clude very much from a single test, the iodine preparation did not 

 appear to be so promising as some other drugs used in these experi- 

 ments. Additional tests should be made. 



LIQUOR CRESOLIS COMP. U. S. P. 



A dose of 4 c. c. of liquor cresolis comp. U. S. P., in 196 c. c. of 

 water given to one pig, resulted in the death of the animal. This 

 preparation is therefore too toxic when used in 4 c. c. doses, and in 

 this test was apparently without value as an anthelmintic. 



